Results 61 to 70 of about 1,688,460 (309)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The risks of learning: confounding detection and demographic trend when using count‐based indices for population monitoring

open access: yesEcology and Evolution, 2014
Theory recognizes that a treatment of the detection process is required to avoid producing biased estimates of population rate of change. Still, one of three monitoring programmes on animal or plant populations is focused on simply counting individuals ...
Vincenzo Gervasi   +4 more
doaj   +1 more source

Error Probability Bounds for Balanced Binary Relay Trees

open access: yes, 2011
We study the detection error probability associated with a balanced binary relay tree, where the leaves of the tree correspond to $N$ identical and independent detectors.
Chong, Edwin K. P.   +4 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Practical fast gate rate InGaAs/InP single-photon avalanche photodiodes

open access: yes, 2009
We present a practical and easy-to-implement method for high-speed near infrared single-photon detection based on InGaAs/InP single-photon avalanche photodiodes (SPADs), combining aspects of both sine gating and self-differencing techniques.
Barreiro, Claudio   +3 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Evaluation of sample collection and storage protocols for surface eDNA surveys of an invasive terrestrial insect

open access: yesEnvironmental DNA, 2022
Environmental DNA surveys have revolutionized monitoring of rare or cryptic species and species inhabiting areas where conventional sampling is difficult or dangerous.
Donnie L. Peterson   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Paired sampling standardizes point count data from humans and acoustic recorders

open access: yesAvian Conservation and Ecology, 2017
Acoustic recordings are increasingly used to quantify occupancy and abundance in avian monitoring and research. The recent development of relatively inexpensive programmable autonomous recording units (ARUs) has further increased the utility of acoustic ...
Steven L. Van Wilgenburg   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

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