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Deterministic Lateral Displacement Microfluidic Chip for Minicell Purification [PDF]

open access: yesMicromachines, 2022
Deterministic lateral displacement (DLD) is a well-known microfluidic technique for particle separation with high potential for integration into bioreactors for therapeutic applications.
Ahmad Sherbaz   +4 more
doaj   +6 more sources

A Review on Deterministic Lateral Displacement for Particle Separation and Detection [PDF]

open access: yesNano-Micro Letters, 2019
The separation and detection of particles in suspension are essential for a wide spectrum of applications including medical diagnostics. In this field, microfluidic deterministic lateral displacement (DLD) holds a promise due to the ability of continuous
Thoriq Salafi, Yi Zhang, Yong Zhang
doaj   +5 more sources

High-Throughput Separation of Long DNA in Deterministic Lateral Displacement Arrays

open access: yesMicromachines, 2022
Length-based separation of DNA remains as relevant today as when gel electrophoresis was introduced almost 100 years ago. While new, long-read genomics technologies have revolutionised accessibility to powerful genomic data, the preparation of samples ...
Oskar E. Ström   +2 more
doaj   +5 more sources

Blood Cell Separation Using Polypropylene-Based Microfluidic Devices Based on Deterministic Lateral Displacement

open access: yesMicromachines, 2023
Mammalian blood cell separation methods contribute to improving the diagnosis and treatment of animal and human diseases. Microfluidic deterministic lateral displacement (DLD) devices can sort cells based on their particle diameter.
Koji Matsuura, Koji Takata
doaj   +3 more sources

Deterministic Lateral Displacement (DLD) Analysis Tool Utilizing Machine Learning towards High-Throughput Separation

open access: yesMicromachines, 2022
Deterministic lateral displacement (DLD) is a microfluidic method for the continuous separation of particles based on their size. There is growing interest in using DLD for harvesting circulating tumor cells from blood for further assays due to its low ...
Eric Gioe   +3 more
doaj   +3 more sources

A High-Aspect-Ratio Deterministic Lateral Displacement Array for High-Throughput Fractionation

open access: yesMicromachines
Future industrial applications of microparticle fractionation with deterministic lateral displacement (DLD) devices are hindered by exceedingly low throughput rates.
Jonathan Kottmeier   +4 more
doaj   +3 more sources

Microfluidic Coupling of Step Emulsification and Deterministic Lateral Displacement for Producing Satellite-Free Droplets and Particles

open access: yesMicromachines, 2023
Step emulsification, which uses a geometry-dependent mechanism for generating uniformly sized droplets, has recently gained considerable attention because of its robustness against flow fluctuations.
Guangchong Ji   +2 more
doaj   +3 more sources

Two-dimensional Simulation of Motion of Red Blood Cells with Deterministic Lateral Displacement Devices

open access: yesMicromachines, 2019
Deterministic lateral displacement (DLD) technology has great potential for the separation, enrichment, and sorting of red blood cells (RBCs). This paper presents a numerical simulation of the motion of RBCs using DLD devices with different pillar shapes
Yanying Jiao, Yongqing He, Feng Jiao
doaj   +3 more sources

Upscaled Production of Satellite-Free Droplets: Step Emulsification with Deterministic Lateral Displacement

open access: yesMicromachines
Step emulsification is a key technique for achieving scalable production of monodisperse emulsion droplets owing to its resilience to flow fluctuations.
Guangchong Ji   +3 more
doaj   +3 more sources

Lubrication Force Saturation Matters for the Critical Separation Size of the Non-Colloidal Spherical Particle in the Deterministic Lateral Displacement Device

open access: yesApplied Sciences, 2022
Deterministic lateral displacement (DLD) is a popular technique for separating micro-scale and nano-scale particles continuously. In this paper, an efficient three-dimensional fictitious domain method is developed for the direct numerical simulation of ...
Zhaosheng Yu, Yutian Yang, Jianzhong Lin
doaj   +3 more sources

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