Particle Separation with Deterministic Lateral Displacement (DLD): The Anisotropy Effect
Proceedings, 2017 Deterministic lateral displacement (DLD) is a passive and label-free microfluidic separation technique with a strong potential for biological sample preparation purposes. Numerical and experimental models have been proposed so far to predict the particle
Eloise Pariset +5 more
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Cell Sorting Using Electrokinetic Deterministic Lateral Displacement
Micromachines, 2020 We show that by combining deterministic lateral displacement (DLD) with electrokinetics, it is possible to sort cells based on differences in their membrane and/or internal structures.
Bao D. Ho +2 more
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Exploiting Device Deformability for Fluid and Particle Manipulation. [PDF]
SmallDeformable devices enable fluid and particle manipulation modes that are inaccessible to rigid platforms. This review examines soft materials and architectures that translate controlled deformation into microscale fluid operations such as pumping, valving, mixing, and particle handling.
Hong Z +4 more
europepmc +2 more sources
Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications. [PDF]
Adv Sci (Weinh)Separating micro/nano‐scale bioparticles from samples is essential for disease diagnosis, prevention, and monitoring. Therefore, a comprehensive overview of the latest advanced separation technologies is provided, and characteristics and limitations based on six key performance parameters, including purity, recovery rate, throughput, resolution, size ...
Lu Q, Zhang Z, Ding X.
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A Review on Deterministic Lateral Displacement for Particle Separation and Detection
Nano-Micro Letters, 2019 The separation and detection of particles in suspension are essential for a wide spectrum of applications including medical diagnostics. In this field, microfluidic deterministic lateral displacement (DLD) holds a promise due to the ability of continuous
Thoriq Salafi, Yi Zhang, Yong Zhang
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High-efficiency isolation of fetal nucleated red blood cells for non-invasive prenatal diagnosis via a cascaded microfluidic platform [PDF]
RSC AdvancesNon-invasive prenatal diagnosis (NIPD) utilizing fetal nucleated red blood cells (fNRBCs) holds great promise for comprehensive genetic analysis; however, its clinical application is challenged by the extreme rarity of these cells in maternal peripheral ...
Hongtao Feng +11 more
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Micromachines, 2019 Deterministic lateral displacement (DLD) technology has great potential for the separation, enrichment, and sorting of red blood cells (RBCs). This paper presents a numerical simulation of the motion of RBCs using DLD devices with different pillar shapes
Yanying Jiao, Yongqing He, Feng Jiao
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Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation. [PDF]
Adv Sci (Weinh)ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
Lundy DJ +8 more
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Upscaled Production of Satellite-Free Droplets: Step Emulsification with Deterministic Lateral Displacement [PDF]
MicromachinesStep emulsification is a key technique for achieving scalable production of monodisperse emulsion droplets owing to its resilience to flow fluctuations.
Guangchong Ji +3 more
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Effective Boundary Correction for Deterministic Lateral Displacement Microchannels to Improve Cell Separation: A Numerical and Experimental Study [PDF]
BiosensorsParticle separation and sorting techniques based on microfluidics have found extensive applications and are increasingly gaining prominence. This research presents the design and fabrication of a microfluidic device for separating cells using ...
Shaghayegh Mirhosseini +7 more
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