Results 51 to 60 of about 25,370 (238)

Pathophysiology of the urothelium and detrusor [PDF]

Canadian Urological Association Journal, 2011
Conventional wisdom now agrees that symptoms of overactivebladder (OAB) seem to emanate from an aberration in the voidingreflex, leading to involuntary detrusor contractions of eitherneurogenic or myogenic origin. Furthermore, emerging evidencealso encourages us to adopt a new paradigm, in which bladderurothelium is not just a simple barrier but an ...
openaire   +3 more sources

The Benefits of Adding Non‐Antimuscarinic Pharmaceuticals in Combination With Beta‐3 Agonists for Overactive Bladder Treatment: A Systematic Review

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Antimuscarinics, as the current first‐line pharmacologic therapies for overactive bladder, exhibit low patient adherence and high rates of reported side effects. As a modern alternative pharmaceutical treatment, beta‐3 agonists, which relax the urinary bladder, may be more tolerable for patients, increasing adherence and ...
Felicity Smith, Charlotte Phelps, Christian Moro   +2 more
wiley   +1 more source

Urothelial dysfunction and sensory protein expressions in patients with urological or systemic diseases and hypersensitive bladder

Urological Science, 2017
Objective: To investigate the underlying pathophysiology in the urothelium of different lower urinary tract diseases (LUTDs) and in patients with overactive bladder (OAB) or hypersensitive bladder (HSB), including chronic inflammation, barrier proteins ...
Hueih-Ling Ong, Hann-Chorng Kuo
doaj   +1 more source

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To investigate the adenosine receptor (AR) mechanism underlying bladder outlet obstruction (BOO)‐related bladder dysfunction, we examined the expression level of AR subtypes in bladder tissues, and the effects of AR subtypes A2B & A3 modulation on bladder activity using male BOO rats, and Dahl rats with A2B receptor deletion. Materials
Masahiro Kurobe, Ei‐ichiro Takaoka, Kanako Matsuoka, Shingo Kimura, Anne M. Robertson, Edwin K. Jackson, Lori A. Birder, Minoru Miyazato, Naoki Yoshimura   +8 more
wiley   +1 more source

Investigation of the Syncytial Nature of Detrusor Smooth Muscle as a Determinant of Action Potential Shape

Frontiers in Physiology, 2018
Unlike most excitable cells, certain syncytial smooth muscle cells are known to exhibit spontaneous action potentials of varying shapes and sizes. These differences in shape are observed even in electrophysiological recordings obtained from a single cell.
Shailesh Appukuttan, Mithun Padmakumar, John S. Young, Keith L. Brain, Keith L. Brain, Rohit Manchanda   +5 more
doaj   +1 more source

Development and Validation of Urodynamic Report Writer: A Chat GPT App

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective Accurate interpretation and reporting of urodynamic studies are essential for diagnosis and management of lower urinary tract dysfunction, yet remain time‐consuming and operator‐dependent. To develop and validate the Urodynamic Report Writer App (URapp), a GPT‐4o‐based virtual assistant that supports interpretation of clinician ...
Riccardo Lombardo, Carolina Cerullo, Marta Santioni, Emanuele Pillitteri, Claudia Lorenti, Sabrina De Cillis, Cristian Fiori, Giorgia Tema, Antonio Franco, Beatrice Turchi, Matteo Romagnoli, Antonio Nacchia, Antonio Cicione, Antonio Pastore, Andrea Fuschi, Andrea Tubaro, Cosimo De Nunzio   +16 more
wiley   +1 more source

Incidence of Urinary Retention Following OnabotulinumtoxinA: A Multi‐Centre Audit Challenging the Necessity of Universal CISC Training

Neurourology and Urodynamics, EarlyView.
ABSTRACT Background Clinical guidelines, such as NICE NG123, prior to OnabotulinumtoxinA (BoNT‐A) injections for overactive bladder (OAB), patients are counselled regarding clean intermittent self‐catheterisation (CISC) and are willing and able to perform catheterisation if required. Subsequently, universal pre‐procedure education imposes a significant
Faysal elzawy, Mark Roger, Shazad Laghari, Ali alali, Mathew Thomas, Prateek Verma   +5 more
wiley   +1 more source

Surgical Treatment of Pelvic Organ Prolapse and Overactive Bladder: A Systematic Review and Meta‐Analysis

Neurourology and Urodynamics, EarlyView.
ABSTRACT Background Pelvic organ prolapse (POP) frequently coexists with overactive bladder (OAB) symptoms, yet the impact of surgical correction on OAB outcomes remains incompletely characterized across different surgical approaches. Objectives To quantify OAB symptom resolution rates following POP surgery, compare outcomes across surgical techniques,
Lorenzo Vacca, Daniela Caramazza, Michele Pierro, Aniello Foresta, Andrea Lombisani, Anna Fagotti, Alfredo Ercoli, Giuseppe Campagna   +7 more
wiley   +1 more source

Urinary Bladder Detrusor Dysfunction Symptoms in Lyme Disease [PDF]

International Neurourology Journal, 2013
Purpose Symptoms of urinary bladder detrusor dysfunction have been rarely reported in Lyme disease. The aim was to carry out the first systematic study to compare the prevalence of such symptoms in a group of Lyme disease patients and a group of matched ...
Basant K. Puri, Mussadiq Shah, Peter O. Julu, Michele C. Kingston, Jean A. Monro   +4 more
doaj   +1 more source

Association Between Toilet Training Timing and Prognosis of Nocturnal Enuresis in Children: A Retrospective Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Toilet training (TT) is a critical developmental milestone with potential implications for lower urinary tract function. However, its association with the prognosis of nocturnal enuresis (NE) remains unclear. We aimed to evaluate whether the timing of TT initiation and completion affects 1‐year treatment outcomes in children with NE ...
Shota Endo, Hirokazu Ikeda, Yuma Iwanaka, Takahiro Ono, Chisato Oyake, Yuta Onuki, Yoshitaka Watanabe, Masaki Fuyama, Tsuneki Watanabe   +8 more
wiley   +1 more source