Results 1 to 10 of about 27,165 (192)

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

Frontiers in Oncology, 2020
Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental cancer therapy by inducing proteasome inhibition and apoptosis. Ferroptosis is a form of regulated cell death characterized by an iron-dependent lipid peroxidation.
Li Yang, Li Yang, Xin Chen, Qianqian Yang, Jinghong Chen, Jinghong Chen, Qingtian Huang, Leyi Yao, Ding Yan, Jiawen Wu, Peiquan Zhang, Daolin Tang, Nanshan Zhong, Jinbao Liu   +13 more
doaj   +2 more sources

USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein

Hepatology Communications, 2023
Background:. The role of thioredoxin-interacting protein (TXNIP) in lipopolysaccharide-induced liver injury in mice has been reported, but the underlying mechanisms are poorly understood. Methods:.
Songchang Shi, Xiaobin Pan, Minyong Chen, Lihui Zhang, Shujuan Zhang, Xincai Wang, Songjing Shi, Zhixin Chen, Wei Lin, Yi Jiang   +9 more
doaj   +1 more source

Deubiquitinase OTUD5 as a Novel Protector against 4‐HNE‐Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Advancement of science, 2023
Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number of patients experience high mortality due to myocardial ischemia‐reperfusion (MI/R) injury.
Lulu Liu, J. Pang, Dandan Qin, Ruochuan Li, D. Zou, Kai Chi, Wenxiao Wu, H. Rui, Huaxiang Yu, Wenyong Zhu, Kai Liu, Xuting Wu, Jinxin Wang, Ping Xu, Xiaoshuai Song, Yihai Cao, Jiali Wang, Feng Xu, L. Xue, Yuguo Chen   +19 more
semanticscholar   +1 more source

Dual function of the Leon/USP5 deubiquitinase in the ubiquitin-proteasome and autophagic pathways

Autophagy Reports, 2023
The ubiquitin-proteasome system (UPS) and autophagy are highly conserved processes that maintain cellular health through the clearance of misfolded/aberrant proteins and damaged organelles.
Yuchieh Jay Lin, Guang-Chao Chen
doaj   +1 more source

The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3

Redox Biology, 2023
Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main contributor and independent risk factor for low back pain (LBP), it would be, therefore, enlightening that investigating the exact pathogenesis of IVDD and ...
Jian Zhu, Ruping Sun, Kaiqiang Sun, Chen Yan, Jia-Jia Jiang, Fanqi Kong, Jian-gang Shi   +6 more
semanticscholar   +1 more source

Journal Staff [PDF]

, 1990
Inhibitors of the catalytic activity of the 20S proteasome are cytotoxic to tumor cells and are currently in clinical use for treatment of multiple myeloma, whilst the deubiquitinase activity associated with the 19S regulatory subunit of the proteasome ...
D'Arcy, Padraig, Fryknäs, Mårten, High, Stephen, Hult, Malin, Linder, Stig, Puumalainen, Marjo-Riitta, Roboti, Peristera, Sun, Chao, Swanton, Eileithyia, Wang, Xin   +9 more
core   +11 more sources

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

Biomolecules, 2021
Dienone compounds with a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore have been widely reported to show tumor cell selectivity. These compounds target the ubiquitin-proteasome system (UPS), known to be essential for the viability of tumor cells.
Karthik Selvaraju, Kourosh Lotfi, Johannes Gubat, Maria Miquel, Amanda Nilsson, Julia Hill, Lasse D. Jensen, Stig Linder, Pádraig D’Arcy   +8 more
doaj   +1 more source

A review of deubiquitinases and thier roles in tumorigenesis and development

Frontiers in Bioengineering and Biotechnology, 2023
Ubiquitin is a small protein that can be added onto target protein for inducing target degradation, thereby modulating the activity and stability of protein.
Xian-Wen Liang, Sheng-Zhong Wang, Bing Liu, Jia-Cheng Chen, Zhi Cao, Feng-Ran Chu, Xiong Lin, Hui Liu, Jin-Cai Wu   +8 more
doaj   +1 more source

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Cell Reports, 2021
Summary: The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development. It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (
Stephanie Patchett, Zongyang Lv, Wioletta Rut, Miklos Békés, Marcin Drag, Shaun K. Olsen, Tony T. Huang   +6 more
doaj   +1 more source

UbiBrowser 2.0: a comprehensive resource for proteome-wide known and predicted ubiquitin ligase/deubiquitinase–substrate interactions in eukaryotic species

Nucleic Acids Res., 2021
As an important post-translational modification, ubiquitination mediates ∼80% of protein degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the delicate balance between specific ubiquitin ligase (E3)-mediated ...
Xun Wang, Yang Li, Mengqi He, X. Kong, Peng Jiang, Xi Liu, Lihong Diao, Xinlei Zhang, Honglei Li, Xinping Ling, Simin Xia, Zhongyang Liu, Yuan Liu, C. Cui, Yan Wang, Liujun Tang, Lingqiang Zhang, F. He, Dong Li   +18 more
semanticscholar   +1 more source