Results 11 to 20 of about 27,265 (285)
Deubiquitinases in Neurodegeneration [PDF]
Cells, 2022 Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly conserved among eukaryotes) to itself or to other proteins through differential use of ubiquitin’s seven internal linkage sites or the amino-terminal amino group ...
Abudu I. Bello +7 more
doaj +3 more sources
Variety in the USP deubiquitinase catalytic mechanism
Life Science AllianceQuantitative analysis shows that USP family members have varying catalytic triads. Their third and fourth catalytic residues change in role and importance for nucleophilic attack and catalysis.
Niels Keijzer +5 more
semanticscholar +3 more sources
Deubiquitinases in hematological malignancies [PDF]
Biomarker Research, 2021 AbstractDeubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of most cellular proteins by removing their ubiquitin modification. In recent years, some DUBs, such as USP7, USP9X and USP10, have been identified as promising therapeutic targets in hematological malignancies.
Hu Lei +4 more
openaire +3 more sources
The role of USP1 deubiquitinase in the pathogenesis and therapy of cancer.
Acta Biochimica Polonica, 2023 Ubiquitin-specific protease 1 (USP1) is an important deubiquitinating enzyme (DUB) involved in the maintenance of genome integrity, cell cycle, and cell homeostasis.
S. Antonenko, M. Zavelevich, G. Telegeev
semanticscholar +1 more source
CYLD: A Multifunctional Deubiquitinase [PDF]
Fly, 2007 The nuclear factor-kappaB (NF-kappaB) and c-Jun NH2-terminal kinase (JNK) signaling pathways regulate diverse biological processes, including the immune and inflammatory response, cell growth, apoptosis, and tumour formation. Not surprisingly therefore defects to either pathway contributes to the progression of numerous human disorders.
Marcus, Glittenberg, Petros, Ligoxygakis
openaire +2 more sources
The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5
Cells, 2023 OTUD5 (OTU Deubiquitinase 5) is a functional cysteine protease with deubiquitinase activity and is a member of the ovarian tumor protease (OTU) family. OTUD5 is involved in the deubiquitination of many key proteins in various cellular signaling pathways ...
Lin Fu, Kun Lu, Q. Jiao, X. Chen, F. Jia
semanticscholar +1 more source
Journal of Biological Chemistry, 2023 Post-translational modifications including protein ubiquitination regulate a plethora of cellular processes in distinct manners. RNA N6-methyladenosine is the most abundant post-transcriptional modification on mammalian mRNAs and plays important roles in
Peipei Wang +9 more
semanticscholar +1 more source
Mechanisms of Deubiquitinase Specificity and Regulation.
Annual Review of Biochemistry, 2017 Protein ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regulates a plethora of cellular processes in distinct manners. Simple monoubiquitination events coexist with more complex forms of polyubiquitination, the latter featuring many different chain architectures.
T. Mevissen, D. Komander
semanticscholar +3 more sources
Communications Biology, 2023 The plant histone deubiquitinase, OTLD1, interacts with the Arabidopsis transcription factor, LSH10, and both transcriptionally regulate a set of common target genes. Histone ubiquitylation/deubiquitylation plays a major role in the epigenetic regulation
Mi Sa Vo Phan +4 more
semanticscholar +1 more source
USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses
Frontiers in Immunology, 2022 Toll-like receptors (TLRs) are involved in the sensing of pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS), flagellin, unmethylated double-stranded DNA (CpG), single-stranded RNA (ssRNA) and lipoproteins.
Na Zhang +12 more
doaj +1 more source