Results 21 to 30 of about 27,265 (285)

VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

Cellular Oncology, 2023
Background The deubiquitinase ovarian tumor domain-containing 1 (OTUD1) has been considered as a tumor suppressor in many tumors, but there is minimal research on the role of OTUD1 in lung adenocarcinoma (LUAD) pathogenesis.
Qi Zhang, Jinglei Li, Zihan Chen, Ke Jiang, Kunyu Yang, Fang Huang, Ai-ying Huang, Xiaodong Zhang, Jinxiang Zhang, Hui Wang   +9 more
semanticscholar   +1 more source

Disulfiram Oxy-Derivatives Suppress Protein Retrotranslocation across the ER Membrane to the Cytosol and Initiate Paraptosis-like Cell Death

Membranes, 2022
Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbamate ...
Marina Solovieva, Yuri Shatalin, Irina Odinokova, Olga Krestinina, Yulia Baburina, Yana Lomovskaya, Anton Pankratov, Natalia Pankratova, Olga Buneeva, Arthur Kopylov, Alexei Medvedev, Vladimir Akatov   +11 more
doaj   +1 more source

CMA-mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination. [PDF]

Clin Transl Med
Deubiquitinase USP9X suppresses SHH Medulloblastoma progression by facilitating SUFU ubiquitination. SHH promotes USP9X degradation through the CMA pathway. Combined inhibition of CMA and SHH pathway had a synergically therapeutic effect on SHH Medulloblastoma.
Gao B, Zhu Q, Kuang L, Li J, Meng Q, Han B, Wang Y, Zhang X, Zhang X, Wang X, Yu T, Yue S, Liu C.   +12 more
europepmc   +2 more sources

Cezanne regulates E2F1-dependent HIF2α expression [PDF]

, 2015
Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Altun, Bangoura, Baudino, Bento, Bett, Bremm, Bremm, Bremm, Budhavarapu, Chiavarina, Cox, Enesa, Fandrey, Fraile, Gordan, Gordan, Holmquist-Mengelbier, Hospenthal, Hu, Hubbi, Ivan, Jaakkola, Keith, Komander, Li, Li, Li, Linehan, Liu, Lukas, Luong, Matsumoto, Meyer, Neumann, Noguera, Pal, Pareja, Raval, Rius, Schumm, Scrideli, Semenza, Shen, Stevens, Troilo, van Uden, Wada, Webster, Yu   +48 more
core   +4 more sources

Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma

Cell Death and Differentiation, 2021
Emerging evidence suggests that USP39 plays an important role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanism by which USP39 promotes HCC progression has not been well defined, especially regarding its putative ...
Xiaomei Li, Jiahui Yuan, Conghua Song, Yongbin Lei, Jiajia Xu, Gongye Zhang, Weiwei Wang, G. Song   +7 more
semanticscholar   +1 more source

Proteasome-associated deubiquitinases and cancer [PDF]

Cancer and Metastasis Reviews, 2017
Maintenance of protein homeostasis is a crucial process for the normal functioning of the cell. The regulated degradation of proteins is primarily facilitated by the ubiquitin proteasome system (UPS), a system of selective tagging of proteins with ubiquitin followed by proteasome-mediated proteolysis.
Mofers, Arjan, Pellegrini, Paola, Linder, Stig, D´arcy, Padraig   +3 more
openaire   +3 more sources

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2020
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. The activation of the toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB (TLR4/MyD88/NF-κB) pathway contributes to the development
Shan Gao, Shan Gao, Tianxiang Chen, Lijie Li, Xin Liu, Yang Liu, Junjun Zhao, Qiliang Lu, Zhi Zeng, Qiuran Xu, Dongsheng Huang, Kangsheng Tu   +11 more
doaj   +1 more source

Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination

Viruses, 2021
The rapid and dynamic activation of the innate immune system is achieved through complex signaling networks regulated by post-translational modifications modulating the subcellular localization, activity, and abundance of signaling molecules.
Valentina Budroni, Gijs A. Versteeg
doaj   +1 more source

Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma [PDF]

, 2018
Table summarizing the RNA-seq results. Differential gene expression results in BAP1-knockdown compared to control OCM-1A cells are shown from the RNA-seq data.
Chen, Xuhua, Cooper, John A, Mitra, Robi D, Onken, Michael D, Qi, Zongtai, Yen, Matthew   +5 more
core   +4 more sources

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.

Molecules and Cells, 2022
The mTOR complex 1 (mTORC1) is an essential metabolic hub that coordinates cellular metabolism with the availability of nutrients, including amino acids.
Dong Wang, Chenchen Xu, Wenyu Yang, Jie Chen, Yuhui Ou, Yuanyuan Guan, Jialiang Guan, Ying Liu   +7 more
semanticscholar   +1 more source