Results 31 to 40 of about 27,265 (285)
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity
EMBO Reports, 2021 Although iron is required for cell proliferation, iron‐dependent programmed cell death serves as a critical barrier to tumor growth and metastasis. Emerging evidence suggests that iron‐mediated lipid oxidation also facilitates immune eradication of ...
Jia Song +7 more
semanticscholar +1 more source
Deubiquitinases in cell death and inflammation
Biochemical Journal, 2022 Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification made by ubiquitin ligases that modulates protein abundance, localization, and/or activity.
Kim Newton, Alexander D. Gitlin
openaire +2 more sources
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit
eLife, 2020 Establishment of translational competence represents a decisive cytoplasmic step in the biogenesis of 40S ribosomal subunits. This involves final 18S rRNA processing and release of residual biogenesis factors, including the protein kinase RIOK1.
Christian Montellese +9 more
doaj +1 more source
Frontiers in Oncology, 2021 Ubiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that USP7 plays a vital role in regulating various physiological and pathological ...
Lin Zhou +6 more
doaj +1 more source
RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]
, 2014 The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S. +2 more
core +1 more source
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
core +2 more sources
Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1
Antioxidants, 2023 Protein ubiquitination, which is catalyzed by ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, is a crucial post-translational modification to regulate numerous cellular functions in a spatio–temporal-specific manner ...
D. Oikawa, K. Shimizu, F. Tokunaga
semanticscholar +1 more source
SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia
Frontiers in Immunology, 2021 SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, in addition to its usual respiratory distress syndrome.
Ritu Mishra, Akhil C. Banerjea
doaj +1 more source
A population-based analysis of germline BAP1 mutations in melanoma [PDF]
, 2017 Germline mutation of the BRCA1 associated protein-1 (BAP1) gene has been linked to uveal melanoma, mesothelioma, meningioma, renal cell carcinoma and basal cell carcinoma.
Adams, DJ +12 more
core +1 more source