Results 71 to 80 of about 27,265 (285)
ElaD, a Deubiquitinating Protease Expressed by E. Coli [PDF]
, 2011 Background: Ubiquitin and ubiquitin-like proteins (Ubl) are designed to modify polypeptides in eukaryotes. Covalent binding of ubiquitin or Ubls to substrate proteins can be reversed by specific hydrolases.
Catic, Andre +3 more
core +1 more source
Journal of Biological Chemistry, 2021 The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein is a key player in tumorigenesis of non–small cell lung cancer (NSCLC) and was recently found to be inactivated by tripartite motif containing 25 (TRIM25)–mediated K63-linked ...
Yuan-ming He +8 more
semanticscholar +1 more source
Journal of Pharmacy and Bioallied SciencesABSTRACT Deubiquitinases are involved in removing ubiquitin (UBQ) from ubiquitylated substrates to regulate their activity and stability. They are involved in various cellular functions including proteasome- and lysosome-dependent proteolysis, gene expression, cell cycle progression, chromosome segregation, kinase ...
Preethi Murali +2 more
openaire +3 more sources
Deubiquitinases in skeletal muscle atrophy [PDF]
The International Journal of Biochemistry & Cell Biology, 2013 The ubiquitin proteasome system plays a critical role in skeletal muscle atrophy. A large body of research has revealed that many ubiquitin ligases are induced and play an important role in mediating the wasting. However, relatively little is known about the roles of deubiquitinases in this process.
openaire +2 more sources
The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
Cell Death and Disease, 2022 Dysregulated abundance, location and transcriptional output of Hippo signaling effector TAZ have been increasingly linked to human cancers including head neck squamous cell carcinoma (HNSCC). TAZ is subjected to ubiquitination and degradation mediated by
Jin Li +8 more
semanticscholar +1 more source
MycologyThe dynamic interplay between pathogens and host immune system determines the outcome of fungal infections. This study investigates the role of Ubp5 in modulating host defenses during Cryptococcus neoformans H99 infections.
Guizhen Wang +4 more
doaj +1 more source
USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity
Biomolecules, 2023 ETS2 is a member of the ETS family of transcription factors and has been implicated in the regulation of cell proliferation, differentiation, apoptosis, and tumorigenesis.
Yunsik Choi +4 more
doaj +1 more source
Nature Communications, 2022 Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear.
A. Vdovin +14 more
semanticscholar +1 more source
A High-Throughput Assay for Monitoring Ubiquitination in Real Time
Frontiers in Chemistry, 2019 Protein ubiquitination is a highly orchestrated process that controls diverse aspects of human biology. Dysregulation of this process can lead to various disease states including cancer, neurodegeneration, and autoimmunity.
Tyler G. Franklin, Jonathan N. Pruneda
doaj +1 more source
Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets
Frontiers in Pharmacology, 2020 Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins.
Chenming Zeng +10 more
doaj +1 more source