Results 151 to 160 of about 10,823 (192)
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Deubiquitinating enzymes: Promising targets for drug resistance
Drug Discovery Today, 2022Drug resistance to chemotherapy and molecularly targeted therapies is a current challenge in cancer treatments. The underlying mechanisms of resistance to cytotoxic chemotherapeutics and to drugs that target a specific molecule are not understood completely.
Fujing, Ge +6 more
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Deubiquitinating Enzymes as Cellular Regulators
Journal of Biochemistry, 2003Modification of proteins by the covalent attachment of ubiquitin is a key regulatory mechanism of many cellular processes including protein degradation by the 26S proteasome. Deubiquitination, reversal of this modification, must also regulate the fate and function of ubiquitin-conjugated proteins.
Jung Hwa, Kim +4 more
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Targeting Deubiquitinating Enzymes
2009Deubiquitinating enzymes (DUBs) or isopeptidases belong to the enzyme class of hydrolases which include more than 100 members identified thus far. These proteins, which are grouped into four cysteine protease families and one metallo-protease family, catalyze the removal of ubiquitin from specific protein targets by cleavage of the linking isopeptide ...
Carmen Priolo +3 more
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Strategies for Assaying Deubiquitinating Enzymes
2005A general method for assaying deubiquitinating enzymes (DUBs) has been developed. This new method employs an indirect enzyme assay for determining the activity of DUBs using a linear fusion of polyHis-glutathione-S-transferase-ubiquitin-ecotin (His-GST-Ub-ecotin) as a substrate. Because ecotin, a trypsin inhibitor protein from Escherichia coli, is heat
Sung Hwan, Kang +4 more
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1998
As detailed elsewhere in this volume, modification of proteins by the 76-residue ubiquitin polypeptide is involved in many aspects of protein metabolism. Among the cellular processes affected by ubiquitin-dependent reactions are chromosome structure and segregation, cell-cycle progression, receptor-mediated signal transduction, gene expression, protein
Keith D. Wilkinson, Mark Hochstrasser
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As detailed elsewhere in this volume, modification of proteins by the 76-residue ubiquitin polypeptide is involved in many aspects of protein metabolism. Among the cellular processes affected by ubiquitin-dependent reactions are chromosome structure and segregation, cell-cycle progression, receptor-mediated signal transduction, gene expression, protein
Keith D. Wilkinson, Mark Hochstrasser
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The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
Nature Medicine, 2018Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis. The deubiquitinase cylindromatosis (CYLD) plays key roles in inflammation and cancer.
Yan-Xiao Ji +23 more
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Deubiquitinating Enzymes: Their Diversity and Emerging Roles
Biochemical and Biophysical Research Communications, 1999A growing number of important regulatory proteins within cells are modified by conjugation of ubiquitin, a well-conserved 76-amino-acid polypeptide. The ubiquitinated proteins are targeted to proteasome for degradation or alternative metabolic fates, such as triggering of plasma membrane endocytosis and trafficking to vacuoles or lysosomes ...
C H, Chung, S H, Baek
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Deubiquitinating Enzymes as Therapeutic Targets in Cancer
Current Pharmaceutical Design, 2013Abnormal regulation of the ubiquitin-proteasome system (UPS) has been known to be involved in the pathogenesis of a variety of human diseases. A number of studies have focused on the identification of small modifiers for the UPS. Even though the proteasome inhibitor Bortezomib (Velcade®) has been approved for the therapy of multiple myeloma and mantle ...
Key-Hwan, Lim, Kwang-Hyun, Baek
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Identification of a Deubiquitinating Enzyme
Science's STKE, 2007Modification of proteins by the covalent attachment of ubiquitin chains has emerged as a major regulatory mechanism in cells. The enzymes that oppose this reaction, the deubiquitinating enzymes, are relatively poorly understood. Kayagaki et al.
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The role of deubiquitinating enzymes in apoptosis
Cellular and Molecular Life Sciences, 2010It has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important regulators of these processes. Cells can be subjected to various stresses and respond in a variety of different ways ranging from activation of survival pathways to ...
Suresh, Ramakrishna +2 more
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