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Deubiquitinating Enzymes: Their Diversity and Emerging Roles
Biochemical and Biophysical Research Communications, 1999A growing number of important regulatory proteins within cells are modified by conjugation of ubiquitin, a well-conserved 76-amino-acid polypeptide. The ubiquitinated proteins are targeted to proteasome for degradation or alternative metabolic fates, such as triggering of plasma membrane endocytosis and trafficking to vacuoles or lysosomes ...
C H, Chung, S H, Baek
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Deubiquitinating Enzymes as Therapeutic Targets in Cancer
Current Pharmaceutical Design, 2013Abnormal regulation of the ubiquitin-proteasome system (UPS) has been known to be involved in the pathogenesis of a variety of human diseases. A number of studies have focused on the identification of small modifiers for the UPS. Even though the proteasome inhibitor Bortezomib (Velcade®) has been approved for the therapy of multiple myeloma and mantle ...
Key-Hwan, Lim, Kwang-Hyun, Baek
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The therapeutic potential of deubiquitinating enzyme inhibitors
Biochemical Society Transactions, 2010Proteases play a key role in various pathological processes and several protease inhibitors are already available for treatment. DUBs (deubiquitinating enzymes) constitute one of the largest classes of human proteases and are key effectors of the ubiquitin–proteasome system.
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Targeting Deubiquitinating Enzymes and Autophagy in Cancer
2016Maintenance of proper cellular homeostasis requires constant surveillance and precise regulation of intracellular protein content. Protein monitoring and degradation is performed by two distinct pathways in a cell: the autophage-lysosome pathway and the ubiquitin-proteasome pathway.
Ashley, Mooneyham, Martina, Bazzaro
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High-throughput screening of functional deubiquitinating enzymes in autophagy
Autophagy, 2021Man Luo, Shouheng Jin
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Deubiquitinating enzymes as possible drug targets for schistosomiasis
Acta Tropica, 2021Fernanda Janku Cabral +2 more
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Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses
Frontiers in Immunology, 2021Han Liu, Yong Jun Yang, Wenying Gao
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Deubiquitinating enzymes in skeletal muscle atrophy—An essential role for USP19
International Journal of Biochemistry and Cell Biology, 2016Simon Wing
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