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Ubiquitin-Modifying Enzymes as Cell-Fate Regulators in Intestinal Inflammation. [PDF]
Qian C +6 more
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UCHL1 promotes temozolomide resistance in glioblastoma by inhibiting the ubiquitination-mediated degradation of keratin 8. [PDF]
Zheng R +9 more
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CircAFF4 inhibits lung cancer progression via destabilizing GPX4 and triggering ferroptosis. [PDF]
Wang J +5 more
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Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response. [PDF]
Qiao K +9 more
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Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes α-synuclein
Biochemical and Biophysical Research Communications, 2023α-synuclein is one of the proteins involved in degenerative neuronal diseases such as Parkinson's disease (PD) or Lewy body dementia (LBD). The pathogenesis is imparted by the abnormal accumulation of α-synuclein resulting in the formation of a Lewy body (LB) and exerting neurotoxicity via an unknown mechanism.
Sang-Soo Park +4 more
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1998
As detailed elsewhere in this volume, modification of proteins by the 76-residue ubiquitin polypeptide is involved in many aspects of protein metabolism. Among the cellular processes affected by ubiquitin-dependent reactions are chromosome structure and segregation, cell-cycle progression, receptor-mediated signal transduction, gene expression, protein
Keith D. Wilkinson, Mark Hochstrasser
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As detailed elsewhere in this volume, modification of proteins by the 76-residue ubiquitin polypeptide is involved in many aspects of protein metabolism. Among the cellular processes affected by ubiquitin-dependent reactions are chromosome structure and segregation, cell-cycle progression, receptor-mediated signal transduction, gene expression, protein
Keith D. Wilkinson, Mark Hochstrasser
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A new map to understand deubiquitination
Biochemical Society Transactions, 2010Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism.
Katz, Elijah J. +2 more
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