Results 141 to 150 of about 22,435 (241)
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei +2 more
wiley +1 more source
Usp49 And H2B Deubiquitination In Chromatin And Cellular Function [PDF]
, 2013 Histones are globular proteins which help package and organize DNA in the eukaryotic nucleus. The four core histones, H2A, H2B, H3 and H4, combine with approximately 146 base pairs of DNA to form a nucleosome, the fundamental unit of chromatin.
Jones, Amanda E
core
Metabolism in Tumor: Mechanisms and Therapeutic Perspectives
MedComm, Volume 7, Issue 9, September 2026.Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng +6 more
wiley +1 more source
Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao +10 more
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.METTL14‐mediated N6‐methyladenosine aggravates ischemia/reperfusion‐induced acute lung injury by enhancing YTHDF1‐dependent USP30 expression. USP30 stabilizes NCOA4 through deubiquitination, thereby promoting ferritinophagy, iron accumulation, lipid peroxidation, and ferroptosis in lung epithelial cells.
Aming Sang +8 more
wiley +1 more source
High‐Content CRISPR Screening: Methods and Applications
MedComm, Volume 7, Issue 9, September 2026.High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang +6 more
wiley +1 more source
The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases
Immunology &Cell Biology, Volume 104, Issue 8, Page 783-793, September 2026.UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng +3 more
wiley +1 more source
SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT Metastatic colon cancer remains a significant clinical challenge, often associated with poor patient prognosis. Recent studies have identified the secreted frizzled‐related protein 2 (SFRP2) as a key player in this malignancy, showing its overexpression in metastatic cases.
Yanshen Kuang +6 more
wiley +1 more source
Figures for "MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis"
0930 Li (13787839)
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