Results 141 to 150 of about 28,234 (247)
Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin [PDF]
Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated protein degradation, or simply ERAD.
Goder, Veit, Lemus Rodríguez,Leticia
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The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei +5 more
wiley +1 more source
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation [PDF]
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the ...
Crews, Craig M. +6 more
core +1 more source
Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application
MedComm, Volume 7, Issue 6, June 2026.The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang +12 more
wiley +1 more source
Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies
MedComm, Volume 7, Issue 6, June 2026.Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge +9 more
wiley +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.This study demonstrates that α‐synuclein expression stabilizes the proteasome activator Blm10, thereby linking α‐synuclein stress to changes in proteasome composition. Blm10/PA200‐capped 20S proteasomes efficiently degrade both monomeric and oligomeric α‐synuclein and remain resistant to α‐synuclein‐induced inhibition.
Tariq T. Ali +7 more
wiley +1 more source
PWO proteins are associated with PRC2 since their emergence in vascular plants
New Phytologist, Volume 250, Issue 6, Page 4002-4021, June 2026.Summary The Polycomb repressive complex 2 (PRC2), a conserved histone methyltransferase complex, plays a central role in transcriptional silencing across eukaryotes. Here, we investigate the evolution of PWWP‐DOMAIN INTERACTORS OF POLYCOMBS (PWOs), which interact with PRC2, and examine the conservation of the PWOs‐PRC2 interaction across plant ...
Ahamed Khan +11 more
wiley +1 more source
PSMD12 promotes hepatocellular carcinoma progression by stabilizing CDK1
Frontiers in ImmunologyProteasome 26S subunit non-ATPase 12 (PSMD12), a critical subunit of the proteasome system, is essential for maintaining protein homeostasis. However, its role in hepatocellular carcinoma (HCC) remains underexplored.
Xingyu Peng +15 more
doaj +1 more source
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis [PDF]
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) chain linkage specific, but comprehensive analyses are missing, and the ...
Akutsu, Masato +12 more
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