Results 121 to 130 of about 28,234 (247)

TrkA abundance is increased in cutaneous nerves in bortezomib‐induced neuropathy

Brain Pathology, Volume 36, Issue 4, July 2026.
Cutaneous nerves in bortezomib‐induced peripheral neuropathy (BIPN) show reduced nerve fiber density, increased TrkA expression, and enhanced dermal angiogenesis, highlighting a pathological switch in NGF/TrkA signaling that may contribute to nerve damage and pain. Abstract Tropomyosin receptor kinase A (TrkA), a high‐affinity receptor for nerve growth
Yuying Jin, Nadine Cebulla, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Johanna Güse, Nicola Giordani, Annett Wieser, Julian Brennecke, Annemarie Sodmann, Martin Kortüm, Robert Blum, Claudia Sommer   +14 more
wiley   +1 more source

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination [PDF]

CYLD negatively regulates the NF-κB signaling pathway and osteoclast differentiation largely through antagonizing TNF receptor-associated factor (TRAF)-mediated K63-linkage polyubiquitination in osteoclast precursor cells.
Deng, Feng, Fukushima, Hidefumi, Inuzuka, Hiroyuki, Nagaoka, Yoshiyuki, Nagashima, Katsuyuki, North, Brian J., Okabe, Koji, Wei, Wenyi, Wu, Xiaomian   +8 more
core   +1 more source

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, Volume 99, Issue 6, Page 1379-1393, June 2026.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

Myricetin inhibits transmissible gastroenteritis virus replication by targeting papain-like protease deubiquitinating enzyme activity

Frontiers in Microbiology
Myricetin, a natural flavonoid found in various foods, was investigated for its antiviral effect against transmissible gastroenteritis virus (TGEV). This α-coronavirus causes significant economic losses in the global swine industry.
Jiahao Fan, Pengyuan Xi, Huimao Liu, Xu Song, Xinghong Zhao, Xun Zhou, Yuanfeng Zou, Yuping Fu, Lixia Li, Renyong Jia, Zhongqiong Yin   +10 more
doaj   +1 more source

Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity [PDF]

Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of life.
Sun, Chao
core   +1 more source

USP5‐C‐MAF Axis Regulates Autophagy‐Dependent Neuronal Ferroptosis in Spinal Cord Injury Therapeutics

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng, Kai Wu, Yinjun Huang, Lei Cao, Huichao Fu   +4 more
wiley   +1 more source

Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis [PDF]

Background The 26S proteasome is at the heart of the ubiquitin-proteasome system, which is the key cellular pathway for the regulated degradation of proteins and enforcement of protein quality control.
Howell, Lauren A., Kusmierczyk, Andrew R., Tomko, Robert J., Jr.   +2 more
core   +1 more source

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

UCHL5 suppresses thyroid carcinoma progression via ZRANB1 stabilization and ferroptosis regulation

Cancer Biology & Therapy
Objective This study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis.Methods We performed multi-omics analysis of TCGA and GEO datasets and validated the ...
Wenxia Xiao, Yu Ding, Xuesuo Wu, Fenglian Que, Baozhi Wang, Shanshan Hong, Fenghua Zhang   +6 more
doaj   +1 more source

Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein [PDF]

Herpesvirus-associated ubiquitin specific protease (HAUSP) regulates the stability of p53 and MDM2, implicating HAUSP as a therapeutic target for tuning p53-mediated anti-tumor activity.
A Dong, A Vagin, A Ventura, AM De Marzo, AT Agoston, C Bronner, CE Petre, CJ Brown, CK Min, CL Brooks, CP Martins, D Komander, E Meulmeester, Eunha Hwang, F Bunz, F Sarkari, GN Murshudov, H Katano, HR Lee, HR Lee, HR Lee, Hye-Ra Lee, Jae U Jung, JM Cummins, JM Gump, JP Kruse, JS Lee, JS Wadia, JT Lee, Juergen Haas, Jungwon Hwang, K Bhatia, Koushik Guchhait, M Hu, M Wade, MN Holowaty, Myung Hee Kim, N Sivachandran, P Emsley, P Uetz, R Zhang, RA Laskowski, RD Everett, S Lain, SA Keller, Stacy Lee, Tae-Kwang Oh, V Saridakis, W Wu, Won-Chan Choi, Y Sheng, Y Yang, Young Ho Jeon, Z Du, Z Otwinowski, Zsolt Toth   +55 more
core   +1 more source