Results 111 to 120 of about 22,435 (241)

Cezanne regulates E2F1-dependent HIF2α expression [PDF]

, 2015
Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Bremm, A., Moniz, Sonia, Komander, David, Bremm, Anja, Campbell, K.J., Campbell, Kirsteen J., Campbell, Kirsteen J, Moniz, S., Biddlestone, John, Komander, D., Rocha, S., Bandarra, D., Biddlestone, J., Bandarra, Daniel, Rocha, Sonia   +14 more
core   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

, 2005
The p53 tumor suppressor protein has a major role in protecting the integrity of the genome. In unstressed cells, p53 is maintained at low levels by the ubiquitin-proteasome pathway. A balance between ubiquitin ligase activity (Hdm2, COP1, and Pirh2) and
Teunisse, A., Meulmeester, E., Maurice, M., Dirks, R., Boutell, C., Ovaa, H., Jochemsen, A., Abraham, T.   +7 more
core   +1 more source

The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation [PDF]

, 2016
SummaryClass switch recombination (CSR) requires activation-induced deaminase (AID) to instigate double-stranded DNA breaks at the immunoglobulin locus.
Conglei Li, Jennifer L. Gommerman, Moffat, Jason, Ramachandran, Shaliny, Dania Haddad, Martin, Alberto, Le, Michael X., Ling, Alexanda K., So, Clare C., Alexanda K. Ling, Li, Conglei, Shaliny Ramachandran, Gommerman, Jennifer L., Yu, Kefei, Michael X. Le, Rajeev M. Nepal, Ketela, Troy, Haddad, Dania, Kefei Yu, Alberto Martin, Troy Ketela, Clare C. So, Nepal, Rajeev M., Jason Moffat   +23 more
core   +1 more source

Insights Into the Origin and Local Adaptation Evolution of the Cultivated Sesame With Telomere‐to‐Telomere High‐Quality Genome

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sesame (Sesamum indicum L., 2n = 26) is one of the oldest oilseed crops and is often called the ‘queen of oilseeds’ due to its high content of unsaturated fatty acids and natural antioxidants. Despite its long history, the origin and global spread of cultivated sesame remain unresolved.
Weifei Yang, Hengchun Cao, Hui Guo, Hongmei Miao, Guiting Li, Yinghui Duan, Ming Ju, Qiuzhen Tian, Qin Ma, Pengjie Chang, Zhanyou Zhang, Cong Mu, Xiaoxu Feng, Libin Wei, Weixiu Hou, Andrew H. Paterson, Haiyang Zhang   +16 more
wiley   +1 more source

Myricetin inhibits transmissible gastroenteritis virus replication by targeting papain-like protease deubiquitinating enzyme activity

Frontiers in Microbiology
Myricetin, a natural flavonoid found in various foods, was investigated for its antiviral effect against transmissible gastroenteritis virus (TGEV). This α-coronavirus causes significant economic losses in the global swine industry.
Jiahao Fan, Pengyuan Xi, Huimao Liu, Xu Song, Xinghong Zhao, Xun Zhou, Yuanfeng Zou, Yuping Fu, Lixia Li, Renyong Jia, Zhongqiong Yin   +10 more
doaj   +1 more source

Proposed model for how CYLD-mediated deubiquitination of LARG enhances the GDP/GTP exchange on RhoA.

, 2013
Proposed model for how CYLD-mediated deubiquitination of LARG enhances the GDP/GTP exchange on RhoA.
Tala (285182), Dengwen Li (285184), Min Liu (45756), Jinmin Gao (285183), Jun Zhou (6477), Lei Sun (45752), Yunfan Yang (285181)   +6 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Editorial: Ubiquitin Code: From Cell Biology to Translational Medicine

Frontiers in Cell and Developmental Biology, 2021
Cui Hua Liu, Cui Hua Liu, Yu Rao, Daming Gao, Lixin Wan, Lingqiang Zhang   +5 more
doaj   +1 more source