Results 91 to 100 of about 19,734 (206)

Insights Into the Origin and Local Adaptation Evolution of the Cultivated Sesame With Telomere‐to‐Telomere High‐Quality Genome

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sesame (Sesamum indicum L., 2n = 26) is one of the oldest oilseed crops and is often called the ‘queen of oilseeds’ due to its high content of unsaturated fatty acids and natural antioxidants. Despite its long history, the origin and global spread of cultivated sesame remain unresolved.
Weifei Yang, Hengchun Cao, Hui Guo, Hongmei Miao, Guiting Li, Yinghui Duan, Ming Ju, Qiuzhen Tian, Qin Ma, Pengjie Chang, Zhanyou Zhang, Cong Mu, Xiaoxu Feng, Libin Wei, Weixiu Hou, Andrew H. Paterson, Haiyang Zhang   +16 more
wiley   +1 more source

Myricetin inhibits transmissible gastroenteritis virus replication by targeting papain-like protease deubiquitinating enzyme activity

Frontiers in Microbiology
Myricetin, a natural flavonoid found in various foods, was investigated for its antiviral effect against transmissible gastroenteritis virus (TGEV). This α-coronavirus causes significant economic losses in the global swine industry.
Jiahao Fan, Pengyuan Xi, Huimao Liu, Xu Song, Xinghong Zhao, Xun Zhou, Yuanfeng Zou, Yuping Fu, Lixia Li, Renyong Jia, Zhongqiong Yin   +10 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Editorial: Ubiquitin Code: From Cell Biology to Translational Medicine

Frontiers in Cell and Developmental Biology, 2021
Cui Hua Liu, Cui Hua Liu, Yu Rao, Daming Gao, Lixin Wan, Lingqiang Zhang   +5 more
doaj   +1 more source

UCHL5 suppresses thyroid carcinoma progression via ZRANB1 stabilization and ferroptosis regulation

Cancer Biology & Therapy
Objective This study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis.Methods We performed multi-omics analysis of TCGA and GEO datasets and validated the ...
Wenxia Xiao, Yu Ding, Xuesuo Wu, Fenglian Que, Baozhi Wang, Shanshan Hong, Fenghua Zhang   +6 more
doaj   +1 more source

Plasma exosomal miR‐339‐3p promotes myocardial remodeling in chronic heart failure by regulating USP25‐mediated DDX58 deubiquitination

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley   +1 more source

Silencing of USP22 promotes FGF11 degradation to attenuates renal fibrosis in diabetic kidney disease

Renal Failure
Objectives: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease that is characterized by renal fibrosis. Fibroblast growth factor 11 (FGF11) is reported to be involved in mesangial cell fibrosis; however, its mechanism is not fully ...
Zhigang Wang, Chao Liu, Jing Lv, Jiping Sun, Xiaoyang Yu, Huixian Li   +5 more
doaj   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases.

PLoS Pathogens
Deubiquitinases (DUBs) remove ubiquitin from substrates and play crucial roles in diverse biological processes. However, our understanding of deubiquitination in viral replication remains limited. Employing an oncogenic human herpesvirus Kaposi's sarcoma-
Shaowei Wang, Xuezhang Tian, Yaru Zhou, Jun Xie, Ming Gao, Yunhong Zhong, Chuchu Zhang, Keying Yu, Lei Bai, Qingsong Qin, Bo Zhong, Dandan Lin, Pinghui Feng, Ke Lan, Junjie Zhang   +14 more
doaj   +1 more source