Results 201 to 210 of about 946,755 (288)
Protein Science, Volume 35, Issue 10, October 2026.Abstract In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding.
Mia Cervantes +5 more
wiley +1 more source
Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek +3 more
wiley +1 more source
Structural and Phase Stability and Deuterium Sorption Behavior of Be<sub>12</sub>Ti Titanium Beryllide Under Simulated Ion Irradiation. [PDF]
Materials (Basel)Dikov A +10 more
europepmc +1 more source
Obesity Reviews, Volume 27, Issue 10, October 2026.ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye +6 more
wiley +1 more source
Water‐Derived Radical Species Initiate Six‐Electron Oxidation of Cyclic Ketones in Microdroplets
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.Spontaneous six‐electron oxidation of cyclic ketones to yield dicarboxylic acids/keto acids is achieved in ethanol microdroplets containing about 2% water under ambient conditions without any metal salts, acids, or oxidants. Mechanistic studies show that trace amounts of water and molecular oxygen serve as active oxidants in this transformation ...
Muhammad Mujahid Ali +3 more
wiley +2 more sources
Controlled Deuteration of Phosphatidylcholine Biosynthetically Produced from Engineered <i>Escherichia coli</i> for SANS Studies. [PDF]
ACS OmegaZhang Q +5 more
europepmc +1 more source
NMR‐Guided Fragment Screening Identifies Privileged Noncanonical Amino Acids for mRNA Display
ChemBioChem, Volume 27, Issue 18, 28 September 2026.A strategy is reported to prescreen and prioritize noncanonical amino acids as fragments prior to their use in mRNA display peptide libraries. Using MDM2 as a target, two ncAAs that bind to the Trp binding pocket in MDM2 are found by protein‐observed NMR.
Abdul J. Castillo +8 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.The first catalytic asymmetric formal [3+2] cycloaddition of allylsilanes delivers cis‐2,5‐disubstituted tetrahydrofuran‐3‐ones that serve as versatile intermediates for the synthesis of diverse bioactive scaffolds. ABSTRACT A formal [3+2] cycloaddition via cyclization/1,2‐hydride shift initiated by nucleophilic attack of allylsilanes has been ...
Hosung Lee +5 more
wiley +2 more sources
Synthesis and In Vivo Incorporation of 4‐Difluoromethyl‐L‐Phenylalanine Into Proteins
ChemBioChem, Volume 27, Issue 18, 28 September 2026.The amino acid 4‐difluoromethyl‐L‐phenylalanine was synthesized and incorporated into full‐length proteins using an orthogonal aminoacyl‐tRNA synthetase (aaRS) with standard genetic code expansion techniques. Subsequent experiments with these proteins show the application of the difluoromethyl group in 19F NMR‐based protein structure studies.
Daniel S. Honeycutt +9 more
wiley +1 more source