Results 21 to 30 of about 14,908,548 (354)
The Chemistry and Pharmacology of Citrus Limonoids [PDF]
Molecules, 2016 Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins.
Roberta Gualdani +3 more
doaj +5 more sources
IgA: Structure, Function, and Developability [PDF]
Antibodies, 2019 Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by infectious microorganisms. Such sites present a major site of susceptibility due to their vast surface area and their constant exposure to ingested and inhaled ...
Patrícia de Sousa-Pereira, J. Woof
semanticscholar +4 more sources
Pioneer: a synthetic human antibody phage display library for rapid therapeutic lead generation [PDF]
mAbsAntibody phage display, a biotechnological method for selecting fully human antibodies from diverse libraries, is firmly established in antibody drug discovery due to its speed and flexibility.
Mateusz Putyrski +12 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2023 Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and nextgeneration sequencing (NGS) in combination with artificial intelligence and machine learning methods (AI/ML) for the identification of de novo humanized ...
Paul Arras +15 more
doaj +1 more source
Accelerating therapeutic protein design with computational approaches toward the clinical stage
Computational and Structural Biotechnology Journal, 2023 Therapeutic protein, represented by antibodies, is of increasing interest in human medicine. However, clinical translation of therapeutic protein is still largely hindered by different aspects of developability, including affinity and selectivity ...
Zhidong Chen +6 more
doaj +1 more source
bioRxiv, 2023 Antibodies with lambda light chains (λ-antibodies) are generally considered to be less developable than those with kappa light chains (κ-antibodies), leading to substantial systematic biases in drug discovery pipelines.
M. Raybould +4 more
semanticscholar +1 more source
mAbs, 2023 Identification of favorable biophysical properties for protein therapeutics as part of developability assessment is a crucial part of the preclinical development process.
A. Waight +10 more
semanticscholar +1 more source
Design of developable surface via CSA-based modification of boundary curves
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020 In this paper, we present a new method for generating high-accuracy developable surface from two design curves via crow search algorithm (CSA) based modification of design curves.
Huanxin CAO, Hongchan ZHENG, Gang HU
doaj +1 more source
Developability Approximation for Neural Implicits Through Rank Minimization [PDF]
International Conference on 3D Vision, 2023 Developability refers to the process of creating a surface without any tearing or shearing from a two-dimensional plane. It finds practical applications in the fabrication industry.
Pratheba Selvaraju
semanticscholar +1 more source
Machine learning prediction of methionine and tryptophan photooxidation susceptibility
Molecular Therapy: Methods & Clinical Development, 2021 Photooxidation of methionine (Met) and tryptophan (Trp) residues is common and includes major degradation pathways that often pose a serious threat to the success of therapeutic proteins.
Jared A. Delmar +6 more
doaj +1 more source