Results 71 to 80 of about 14,908,548 (354)

Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity

mAbs, 2023
Bispecific antibodies continue to represent a growth area for antibody therapeutics, with roughly a third of molecules in clinical development being T-cell engagers that use an anti-CD3 binding arm.
Catherine Y Liu, Cory L Ahonen, Michael E Brown, Ling Zhou, Martin Welin, Eric M Krauland, Robert Pejchal, Paul F Widboom, Michael B Battles   +8 more
doaj   +1 more source

Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity assessment

mAbs
Precise measurement of the binding activity changes of therapeutic antibodies is important to determine the potential critical quality attributes (CQAs) in developability assessment at the early stage of antibody development.
Shuai Wang, Yanqi Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu   +12 more
semanticscholar   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Rigidity and regularity of co-dimension one Sobolev isometric immersions [PDF]

, 2013
We prove the developability and $C^{1,1/2}$ regularity of $W^{2,2}$ isometric immersions of $n$-dimensional domains into $R^{n+1}$. As a conclusion we show that any such Sobolev isometry can be approximated by smooth isometries in the $W^{2,2}$ strong ...
Mohammad, Reza Pakzad, Zhuomin Liu
core  

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Metrization of Weakly Developable Spaces

Sultan Qaboos University Journal for Science, 2002
In this note, we present metrization of weak developability.
Abdul M. Mohamad
doaj   +1 more source

Triangular Bézier Developable Patches [PDF]

, 2009
Developable surfaces are defined as zero gaussian curvature surfaces (intrinsically flat). That is, plane patches that are curved by just folding, rolling or cutting, but without stretching or combing.
Fernández Jambrina, Leonardo
core  

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Developing developments

Theoretical Computer Science, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

A First Insight into the Developability of an Immunoglobulin G3: A Combined Computational and Experimental Approach

bioRxiv
Immunoglobulin G 3 (IgG3) monoclonal antibodies (mAbs) are high value scaffolds for developing novel therapies. Despite their wide-ranging therapeutic potential, IgG3 physicochemical properties and developability characteristics remain largely under ...
G. B. Armstrong, Alan Lewis, Vidhi Shah, P. Taylor, Craig Jamieson, Glenn A Burley, William Lewis, Z. Rattray   +7 more
semanticscholar   +1 more source