Results 1 to 10 of about 74,177 (135)

Reducing the risk of criminal exploitation using multi-systemic therapy (the RESET Study): study protocol for a feasibility study and process evaluation

Pilot and Feasibility Studies, 2023
Background Child criminal exploitation is a form of child abuse that poses a serious risk to the welfare, safety, and wellbeing of young people. Multisystemic therapy (MST) is an intensive family and community-based intervention for young people with ...
N. K. Hayden, S. Flynn, F. Blumenfeld, R. P. Hastings, K. M. Gray, S. Cullen, M. A. Cullen, P. E. Langdon   +7 more
doaj   +1 more source

White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile

Molecular Autism, 2020
Background Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was
Haruhisa Ohta, Yuta Y. Aoki, Takashi Itahashi, Chieko Kanai, Junya Fujino, Motoaki Nakamura, Nobumasa Kato, Ryu-ichiro Hashimoto   +7 more
doaj   +1 more source

Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Acta Neuropathologica Communications, 2022
The increased life expectancy of individuals with Down syndrome (DS) is associated with increased prevalence of trisomy 21–linked early-onset Alzheimer’s disease (EOAD) and dementia.
Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P. Silverman, Thomas Wisniewski   +11 more
doaj   +1 more source

Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism

Acta Neuropathologica Communications, 2020
Autism, the most frequent neurodevelopmental disorder of a very complex etiopathology, is associated with dysregulation of cellular homeostatic mechanisms, including processing of amyloid-β precursor protein (APP).
Janusz Frackowiak, Bozena Mazur-Kolecka, Pankaj Mehta, Jerzy Wegiel   +3 more
doaj   +1 more source

Attitudes toward risk and ambiguity in patients with autism spectrum disorder

Molecular Autism, 2017
Although the ability to make optimal decisions under uncertainty is an integral part of everyday life, individuals with autism spectrum disorder (ASD) frequently report that they experience difficulties with this skill.
Junya Fujino, Shisei Tei, Ryu-ichiro Hashimoto, Takashi Itahashi, Haruhisa Ohta, Chieko Kanai, Rieko Okada, Manabu Kubota, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi   +10 more
doaj   +1 more source

P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells

Nature Communications, 2022
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to ...
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum   +21 more
doaj   +1 more source

Increased reward value of nonsocial stimuli in children and adolescents with autism

Frontiers in Psychology, 2015
We used an econometric choice task to estimate the implicit reward value of social and nonsocial stimuli related to restricted interests in children and adolescents with (n=12) and without (n=22) ASD.
Karli K Watson, Stephanie eMiller, Eleanor eHanna, Megan eKovac, Cara R Damiano, Antoinette eSabatino-DiCrisco, Lauren eTurner-Brown, Noah J. Sasson, Michael Louis Platt, Gabriel S Dichter   +9 more
doaj   +1 more source

Chronic Cerebral Hypoperfusion Causes Decrease of O-GlcNAcylation, Hyperphosphorylation of Tau and Behavioral Deficits in Mice

Frontiers in Aging Neuroscience, 2014
Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD).
Yang eZhao, Yang eZhao, Jin-hua eGu, Jin-hua eGu, Chun-ling eDai, Qun eLiu, Khalid eIqbal, Fei eLiu, CHENG-XIN eGONG   +8 more
doaj   +1 more source

Deficit of corpus callosum axons, reduced axon diameter and decreased area are markers of abnormal development of interhemispheric connections in autistic subjects

Acta Neuropathologica Communications, 2018
Introduction In autism spectrum disorder, lack of coherence and of complex information processing, and narrowly focused interests and repetitive behaviors are considered a sign of long-range underconnectivity and short-range overconnectivity. The goal of
Jarek Wegiel, Wojciech Kaczmarski, Michael Flory, Veronica Martinez-Cerdeno, Thomas Wisniewski, Krzysztof Nowicki, Izabela Kuchna, Jerzy Wegiel   +7 more
doaj   +1 more source

Hyperphosphorylation-induced tau oligomers

Frontiers in Neurology, 2013
In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the protein and at this level of phosphorylation it is a soluble cytosolic protein.
Khalid eIqbal, CHENG-XIN eGONG, Fei eLiu
doaj   +1 more source