Results 81 to 90 of about 7,143,981 (292)
miR-424(322)~503 impairs colon cancer progression driven by PTEN deficiency
Cell Death and DiseaseColorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, with molecular subtypes and signaling pathways playing critical roles in its progression.
Maria Vidal-Sabanés +10 more
doaj +1 more source
A Drosophila model for developmental nicotine exposure.
PLoS ONE, 2017 Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood.
Norma Andrea Velazquez-Ulloa
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Developmental imaging genetics: challenges and promises for translational research [PDF]
, 2006 Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework.
Viding, E. +2 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Formation of the Middle Ear: Recent Progress on the Developmental and Molecular Mechanisms
Developmental Biology, 2001 The middle ear allows animals to hear while moving in an aerial medium. It is composed of a cavity harbouring a chain of three ossicles that transmit vibrations produced by airborne sound in the tympanic membrane into the inner ear, where they are converted into neural impulses.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Evolutionary Conservation of Organ Development between Drosophila and Mammals
Shiyan dongwu yu bijiao yixueDrosophila， as a classic model organism， exhibits high evolutionary conservation with mammals in molecular regulatory networks， signal pathway transduction， and cell fate determination mechanisms involved in its organ development.
GAO Yinghao, WU Wei
doaj +1 more source
F1000Research, 2014 One of the most striking patterns in comparative biology is the negative correlation between lifespan and fecundity observed in comparisons among species.
Yingxue Ren, Kimberly A. Hughes
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source