Results 61 to 70 of about 1,176,068 (282)

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

iScience, 2020
Summary: Autism susceptibility candidate 2 (AUTS2), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we investigated ...
Kunihiko Yamashiro, Kei Hori, Esther S.K. Lai, Ryo Aoki, Kazumi Shimaoka, Nariko Arimura, Saki F. Egusa, Asami Sakamoto, Manabu Abe, Kenji Sakimura, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano, Mikio Hoshino   +13 more
doaj   +1 more source

Can neuroscience construct a literate gendered culture? [PDF]

, 2011
The construction of boys as a gendered culture is not usually associated with neuroscience. Exceptions are publications and presentations by consultants on boys’ education who adopt a “brain-based” perspective.
Whitehead, David
core  

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation

iScience
Summary: Neurons in the neocortex are generated during embryonic development. While the adult ventricular-subventricular zone (V-SVZ) contains cells with neural stem/progenitors’ characteristics, it remains unclear whether it has the capacity of ...
Caroline A. Kopsidas, Clara C. Lowe, Dennis P. McDaniel, Xiaoming Zhou, Yuanyi Feng   +4 more
doaj   +1 more source

Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

iScience, 2022
Summary: Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2).
Urko del Castillo, Rosalind Norkett, Wen Lu, Anna Serpinskaya, Vladimir I. Gelfand   +4 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Development of sensorimotor-visual connectome gradient at birth predicts neurocognitive outcomes at 2 years of age

iScience
Summary: Functional connectome gradients represent fundamental organizing principles of the brain. Here, we report the development of the connectome gradients in preterm and term babies aged 31–42 postmenstrual weeks using task-free functional MRI and ...
Yunman Xia, Jianlong Zhao, Yuehua Xu, Dingna Duan, Mingrui Xia, Tina Jeon, Minhui Ouyang, Lina Chalak, Nancy Rollins, Hao Huang, Yong He   +10 more
doaj   +1 more source

Developmental neuroscience [PDF]

Current Opinion in Neurobiology, 2011
Arber, Silvia, Davis, Graeme
openaire   +6 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

The future of neuroscience in developmental psychopathology

Development and Psychopathology
AbstractDevelopmental psychopathology started as an intersection of fields and is now a field itself. As we contemplate the future of this field, we consider the ways in which a newer, interdisciplinary field – human developmental neuroscience – can inform, and be informed by, developmental psychopathology.
Luke W. Hyde, Jessica L. Bezek, Cleanthis Michael   +2 more
openaire   +2 more sources