Results 41 to 50 of about 1,176,068 (282)

A developmental social neuroscience model for understanding loneliness in adolescence

, 2018
Loneliness is prevalent in adolescents. Although it can be a normative experience, children and adolescents who experience loneliness are often at risk for anxiety, depression, and suicide.
Yeung, PPS, Wong, NML, Lee, TMC
core   +1 more source

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain

iScience, 2019
Summary: Since the generation of cell-type specific knockout models, the importance of inter-cellular communication between neural, vascular, and microglial cells during neural development has been increasingly appreciated.
Bilal N. Sheikh, Olga Bondareva, Sukanya Guhathakurta, Tsz Hong Tsang, Katarzyna Sikora, Nadim Aizarani, Sagar, Herbert Holz, Dominic Grün, Lutz Hein, Asifa Akhtar   +10 more
doaj   +1 more source

White matter protection with insulin-like growth factor 1 and hypothermia is not additive after severe reversible cerebral ischemia in term fetal sheep

, 2011
Moderate cerebral hypothermia significantly improves survival without disability from perinatal hypoxia-ischemia. However, protection is partial. Insulin-like growth factor 1 (IGF-1) plays a key role in oligodendrocyte survival and myelination.
J. Bouwmans, L. Bennet, L. Weaver-Mikaere, George, Sherly, Bennet, Laura, S. Mathai, M. Fraser, Weaver-Mikaere, Luke, Skinner, SJM, Mathai, S, Fraser, Mhoyra, A.J. Gunn, S.J.M. Skinner, Gunn, Alistair, S. George, Bouwmans, J   +15 more
core   +1 more source

Behavioral observation of xenopus tadpole swimming for neuroscience labs [PDF]

, 2014
Neuroscience labs benefit from reliable, easily - monitored neural responses mediated by well - studied neural pathways . Xenopus laevis tadpoles have been used as a simple vertebrate model preparation in motor control studies.
Porter, Nicola Jean, Li, Wenchang, Wagner, Monica Anne   +2 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex

iScience
Summary: Phosphatidylinositol (PI) is highly enriched in arachidonic acid, an essential polyunsaturated fatty acid for brain development. This enrichment is mediated by the phospholipid remodeling enzyme lysophospholipid acyltransferase 11 (LPLAT11 ...
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Yukiko Gotoh, Junken Aoki, Nozomu Kono   +7 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Neuroscience Needs Network Science [PDF]

, 2023
The brain is a complex system comprising a myriad of interacting neurons, posing significant challenges in understanding its structure, function, and dynamics.
Bullmore, E, Sporns, O, Kovács, IA, Hernán Makse, Christos Papadimitriou, Albert-László Barabási, György Buzsáki, Hongkui Zeng, Bianconi, G, Ed Bullmore, Zador, AM, Tina Eliassi-Rad, Thomas E. Nichols, Towlson, EK, Zeng, H, Anthony M. Zador, Buzsáki, G, Kim Stachenfeld, Burgess, M, Nichols, TE, Olaf Sporns, Amy Bernard, Barabási, DL, Dileep George, Emma K. Towlson, Bernard, A, Stachenfeld, K, Mark Burgess, SueYeon Chung, Zoltán Toroczkai, Chung, S, Dániel L. Barabási, George, D, Ginestra Bianconi, Eliassi-Rad, T, István A. Kovács, Makse, H, Barabási, A-L, Toroczkai, Z, Papadimitriou, C   +39 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children

Translational Psychiatry, 2022
Autistic traits represent a continuum dimension across the population, with autism spectrum disorder (ASD) being the extreme end of the distribution. Accumulating evidence shows that neuroanatomical and neurofunctional profiles described in relatives of ...
Raffaele Mazziotti, Elena Scaffei, Eugenia Conti, Viviana Marchi, Riccardo Rizzi, Giovanni Cioni, Roberta Battini, Laura Baroncelli   +7 more
doaj   +1 more source