Results 41 to 50 of about 1,182,997 (280)

The neural reuse hypothesis

, 2020
In this chapter, the authors propose neural reuse as a promising unifying framework for the advance of developmental cognitive neuroscience. In order to do so, first, the authors describe the hypothesis of neural reuse and some of the evidence for its ...
Penner, Marcie, Anderson, Michael L, Raja, Vicente, Uddin, Lucina Q, Lucina Q. Uddin, Vicente Raja, Marcie Penner, Michael L. Anderson   +7 more
core   +2 more sources

Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood

iScience, 2021
Summary: In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender   +7 more
doaj   +1 more source

Editorial: Social and Emotional Influences on Human Development: Perspectives From Developmental Neuroscience. [PDF]

Front Psychol, 2018
The relevance of emotional and social processes in human development is a central focus in developmental psychology (for an overview see Eisenberg, 2006).
Ferdinand NK, Paulus M, Schuwerk T, Kühn-Popp N.   +3 more
europepmc   +2 more sources

Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior

iScience
Summary: Drinking and feeding are tightly coordinated homeostatic events and the paraventricular nucleus of the hypothalamus (PVH) represents a possible node of neural integration for signals related to energy and fluid homeostasis.
Serena R. Sweet, Jessica E. Biddinger, Jessie B. Zimmermann, Gina L. Yu, Richard B. Simerly   +4 more
doaj   +1 more source

KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner

iScience, 2022
Summary: A growing body of human literature implicates KIBRA in memory and neurodevelopmental disorders. Memory and the cellular substrates supporting adaptive cognition change across development.
Matthew L. Mendoza, Lilyana D. Quigley, Thomas Dunham, Lenora J. Volk   +3 more
doaj   +1 more source

A developmental social neuroscience model for understanding loneliness in adolescence

, 2018
Loneliness is prevalent in adolescents. Although it can be a normative experience, children and adolescents who experience loneliness are often at risk for anxiety, depression, and suicide.
Yeung, PPS, Wong, NML, Lee, TMC
core   +1 more source

Journal of Neuroscience [PDF]

The nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here, we discuss how the field of "developmental systems neuroscience" combines the molecular and genetic perspectives of developmental ...
Dooley, James C., van der Heijden, Meike E.   +1 more
core   +1 more source

miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance

iScience
Summary: Vertebrate commissural axon (CA) projection and midline crossing require suppression of Slit responsiveness in precrossing axons and its upregulation in postcrossing axons.
Bhakti Khot, Harindi Suriyaarachchi, Tanushree Majumder, Anagaa Nathan, Q. Richard Lu, Guofa Liu   +5 more
doaj   +1 more source

Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro

iScience, 2022
Summary: Human fetal membrane mesenchymal stromal cells (hFM-MSCs) are a cell population easily isolable from the amniochorionic membrane of term placentas, without ethical issues or safety limitations.
Giulia Gaggi, Andrea Di Credico, Simone Guarnieri, Maria Addolorata Mariggiò, Patrizia Ballerini, Angela Di Baldassarre, Barbara Ghinassi   +6 more
doaj   +1 more source

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain

iScience, 2019
Summary: Since the generation of cell-type specific knockout models, the importance of inter-cellular communication between neural, vascular, and microglial cells during neural development has been increasingly appreciated.
Bilal N. Sheikh, Olga Bondareva, Sukanya Guhathakurta, Tsz Hong Tsang, Katarzyna Sikora, Nadim Aizarani, Sagar, Herbert Holz, Dominic Grün, Lutz Hein, Asifa Akhtar   +10 more
doaj   +1 more source