Results 41 to 50 of about 163,366 (294)

Are developmental disorders like cases of adult brain damage? Implications from connectionist modelling [PDF]

, 2002
It is often assumed that similar domain-specific behavioural impairments found in cases of adult brain damage and developmental disorders correspond to similar underlying causes, and can serve as convergent evidence for the modular structure of the ...
Thomas, Michael S.C., Thomas, MSC, Karmiloff-Smith, Annette, Karmiloff-Smith, A   +3 more
core   +1 more source

miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance

iScience
Summary: Vertebrate commissural axon (CA) projection and midline crossing require suppression of Slit responsiveness in precrossing axons and its upregulation in postcrossing axons.
Bhakti Khot, Harindi Suriyaarachchi, Tanushree Majumder, Anagaa Nathan, Q. Richard Lu, Guofa Liu   +5 more
doaj   +1 more source

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain

iScience, 2019
Summary: Since the generation of cell-type specific knockout models, the importance of inter-cellular communication between neural, vascular, and microglial cells during neural development has been increasingly appreciated.
Bilal N. Sheikh, Olga Bondareva, Sukanya Guhathakurta, Tsz Hong Tsang, Katarzyna Sikora, Nadim Aizarani, Sagar, Herbert Holz, Dominic Grün, Lutz Hein, Asifa Akhtar   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

White matter protection with insulin-like growth factor 1 and hypothermia is not additive after severe reversible cerebral ischemia in term fetal sheep

, 2011
Moderate cerebral hypothermia significantly improves survival without disability from perinatal hypoxia-ischemia. However, protection is partial. Insulin-like growth factor 1 (IGF-1) plays a key role in oligodendrocyte survival and myelination.
J. Bouwmans, L. Bennet, L. Weaver-Mikaere, George, Sherly, Bennet, Laura, S. Mathai, M. Fraser, Weaver-Mikaere, Luke, Skinner, SJM, Mathai, S, Fraser, Mhoyra, A.J. Gunn, S.J.M. Skinner, Gunn, Alistair, S. George, Bouwmans, J   +15 more
core   +1 more source

LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex

iScience
Summary: Phosphatidylinositol (PI) is highly enriched in arachidonic acid, an essential polyunsaturated fatty acid for brain development. This enrichment is mediated by the phospholipid remodeling enzyme lysophospholipid acyltransferase 11 (LPLAT11 ...
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Yukiko Gotoh, Junken Aoki, Nozomu Kono   +7 more
doaj   +1 more source

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

iScience, 2020
Summary: Autism susceptibility candidate 2 (AUTS2), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we investigated ...
Kunihiko Yamashiro, Kei Hori, Esther S.K. Lai, Ryo Aoki, Kazumi Shimaoka, Nariko Arimura, Saki F. Egusa, Asami Sakamoto, Manabu Abe, Kenji Sakimura, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano, Mikio Hoshino   +13 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children

Translational Psychiatry, 2022
Autistic traits represent a continuum dimension across the population, with autism spectrum disorder (ASD) being the extreme end of the distribution. Accumulating evidence shows that neuroanatomical and neurofunctional profiles described in relatives of ...
Raffaele Mazziotti, Elena Scaffei, Eugenia Conti, Viviana Marchi, Riccardo Rizzi, Giovanni Cioni, Roberta Battini, Laura Baroncelli   +7 more
doaj   +1 more source

Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

iScience, 2022
Summary: Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2).
Urko del Castillo, Rosalind Norkett, Wen Lu, Anna Serpinskaya, Vladimir I. Gelfand   +4 more
doaj   +1 more source