Results 41 to 50 of about 407,893 (295)

Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

iScience, 2021
Summary: N6-methyladenosine (m6A) is emerging as a vital factor regulating neural differentiation. Here, we report that deficiency of Arhgef2, a novel cause of a neurodevelopmental disorder we identified recently, impairs neurogenesis, neurite outgrowth,
Pei Zhou, Yifei Qi, Xiang Fang, Miaomiao Yang, Shuxin Zheng, Caihua Liao, Fengying Qin, Lili Liu, Hong Li, Yan Li, Ethiraj Ravindran, Chuanbo Sun, Xinshu Wei, Wen Wang, Liang Fang, Dingding Han, Changgeng Peng, Wei Chen, Na Li, Angela M. Kaindl, Hao Hu   +20 more
doaj   +1 more source

Cross-frequency phase-amplitude coupling as a mechanism for temporal orienting of attention in childhood [PDF]

, 2018
Temporal orienting of attention operates by biasing the allocation of cognitive and motor resources in specific moments in time, resulting in the improved processing of information from expected compared with unexpected targets.
Astle, Duncan E., Mento, Giovanni, Scerif, Gaia   +2 more
core   +1 more source

miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance

iScience
Summary: Vertebrate commissural axon (CA) projection and midline crossing require suppression of Slit responsiveness in precrossing axons and its upregulation in postcrossing axons.
Bhakti Khot, Harindi Suriyaarachchi, Tanushree Majumder, Anagaa Nathan, Q. Richard Lu, Guofa Liu   +5 more
doaj   +1 more source

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain

iScience, 2019
Summary: Since the generation of cell-type specific knockout models, the importance of inter-cellular communication between neural, vascular, and microglial cells during neural development has been increasingly appreciated.
Bilal N. Sheikh, Olga Bondareva, Sukanya Guhathakurta, Tsz Hong Tsang, Katarzyna Sikora, Nadim Aizarani, Sagar, Herbert Holz, Dominic Grün, Lutz Hein, Asifa Akhtar   +10 more
doaj   +1 more source

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

iScience, 2020
Summary: Autism susceptibility candidate 2 (AUTS2), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we investigated ...
Kunihiko Yamashiro, Kei Hori, Esther S.K. Lai, Ryo Aoki, Kazumi Shimaoka, Nariko Arimura, Saki F. Egusa, Asami Sakamoto, Manabu Abe, Kenji Sakimura, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano, Mikio Hoshino   +13 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex

iScience
Summary: Phosphatidylinositol (PI) is highly enriched in arachidonic acid, an essential polyunsaturated fatty acid for brain development. This enrichment is mediated by the phospholipid remodeling enzyme lysophospholipid acyltransferase 11 (LPLAT11 ...
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Yukiko Gotoh, Junken Aoki, Nozomu Kono   +7 more
doaj   +1 more source

A connectomic approach to the lateral geniculate nucleus [PDF]

, 2017
Although the core functions and structure of the lateral geniculate nucleus (LGN) are well understood, this core is surrounded by questions about the integration of feedforward and feedback connections, interactions between different channels of ...
Morgan, Josh L
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation

iScience, 2019
Summary: Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with cereblon (CRBN), a substrate receptor subunit of the CRL4 E3 ubiquitin ligase complex.
Hideki Ando, Tomomi Sato, Takumi Ito, Junichi Yamamoto, Satoshi Sakamoto, Nobuhiro Nitta, Tomoko Asatsuma-Okumura, Nobuyuki Shimizu, Ryota Mizushima, Ichio Aoki, Takeshi Imai, Yuki Yamaguchi, Arnold J. Berk, Hiroshi Handa   +13 more
doaj   +1 more source