Results 51 to 60 of about 1,176,068 (282)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
iScienceSummary: The corpus callosum (CC) is a major nerve bundle that connects the two hemispheres of the brain. Dysgenesis of the CC is associated with neurodevelopmental disorders such as the CTNNB1 syndrome.
Arpan Parichha +11 more
doaj +1 more source
Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation
iScience, 2019 Summary: Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with cereblon (CRBN), a substrate receptor subunit of the CRL4 E3 ubiquitin ligase complex.
Hideki Ando +13 more
doaj +1 more source
Developmental cognitive neuroscience: progress and potential [PDF]
Trends in Cognitive Sciences, 2004 Developmental cognitive neuroscience is an evolving field that investigates the relations between neural and cognitive development. Lying at the intersection of diverse disciplines, work in this area promises to shed light on classic developmental questions, mechanisms subserving developmental change, diagnosis and treatment of developmental disorders,
Yuko, Munakata +2 more
openaire +2 more sources
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Developmental arcs of plasticity in whole movement repertoires of a clonal fish
iScienceSummary: Developmental plasticity at the behavioral repertoire level allows animals to incrementally adjust their behavioral phenotypes to match their environments through ontogeny.
Sean M. Ehlman +5 more
doaj +1 more source
Cognitive and affective neuroscience and developmental psychopathology [PDF]
Development and Psychopathology, 2005 Can the connection between psychology and neuroscience provide a sufficient framework to support the study of the development of maladaptation and psychopathology? This Special Issue is devoted to papers that address this general issue within their specific domains.
Dante, Cicchetti, Michael I, Posner
openaire +2 more sources
Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates [PDF]
, 2017 This is the peer-reviewed but unedited manuscript version of the following article: Lee, W. L. A., et al. (2017). "Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates." Developmental Neuroscience 39(1-4): 49-58.
Wei Ling Amelia Lee +5 more
core +1 more source
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source