Results 31 to 40 of about 1,176,068 (282)

Development and cadherin-mediated control of prefrontal corticostriatal projections in mice

iScience, 2023
Summary: Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developing ...
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson   +11 more
doaj   +1 more source

Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation

iScience, 2022
Summary: FBXO41 is a neuron-specific E3 ligase subunit implicated in epileptic encephalopathies. Fbxo41 null mutant (KO) mice show behavioral deficits and early lethality.
Ana R.A.A. Quadros, Rocío Díez Arazola, Andrea Romaguera Álvarez, Johny Pires, Rhiannon M. Meredith, Ingrid Saarloos, Matthijs Verhage, Ruud F. Toonen   +7 more
doaj   +1 more source

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

iScience, 2020
Summary: Mammalian brain development critically depends on proper thyroid hormone signaling, via the TRα1 nuclear receptor. The downstream mechanisms by which TRα1 impacts brain development are currently unknown. In order to investigate these mechanisms,
Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant   +6 more
doaj   +1 more source

Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

iScience, 2021
Summary: N6-methyladenosine (m6A) is emerging as a vital factor regulating neural differentiation. Here, we report that deficiency of Arhgef2, a novel cause of a neurodevelopmental disorder we identified recently, impairs neurogenesis, neurite outgrowth,
Pei Zhou, Yifei Qi, Xiang Fang, Miaomiao Yang, Shuxin Zheng, Caihua Liao, Fengying Qin, Lili Liu, Hong Li, Yan Li, Ethiraj Ravindran, Chuanbo Sun, Xinshu Wei, Wen Wang, Liang Fang, Dingding Han, Changgeng Peng, Wei Chen, Na Li, Angela M. Kaindl, Hao Hu   +20 more
doaj   +1 more source

Models of atypical development must also be models of normal development [PDF]

, 2002
Functional magnetic resonance imaging studies of developmental disorders and normal cognition that include children are becoming increasingly common and represent part of a newly expanding field of developmental cognitive neuroscience. These studies have
Westermann, G, Mareschal, D
core   +4 more sources

Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood

iScience, 2021
Summary: In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender   +7 more
doaj   +1 more source

Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior

iScience
Summary: Drinking and feeding are tightly coordinated homeostatic events and the paraventricular nucleus of the hypothalamus (PVH) represents a possible node of neural integration for signals related to energy and fluid homeostasis.
Serena R. Sweet, Jessica E. Biddinger, Jessie B. Zimmermann, Gina L. Yu, Richard B. Simerly   +4 more
doaj   +1 more source

KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner

iScience, 2022
Summary: A growing body of human literature implicates KIBRA in memory and neurodevelopmental disorders. Memory and the cellular substrates supporting adaptive cognition change across development.
Matthew L. Mendoza, Lilyana D. Quigley, Thomas Dunham, Lenora J. Volk   +3 more
doaj   +1 more source

miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance

iScience
Summary: Vertebrate commissural axon (CA) projection and midline crossing require suppression of Slit responsiveness in precrossing axons and its upregulation in postcrossing axons.
Bhakti Khot, Harindi Suriyaarachchi, Tanushree Majumder, Anagaa Nathan, Q. Richard Lu, Guofa Liu   +5 more
doaj   +1 more source

Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro

iScience, 2022
Summary: Human fetal membrane mesenchymal stromal cells (hFM-MSCs) are a cell population easily isolable from the amniochorionic membrane of term placentas, without ethical issues or safety limitations.
Giulia Gaggi, Andrea Di Credico, Simone Guarnieri, Maria Addolorata Mariggiò, Patrizia Ballerini, Angela Di Baldassarre, Barbara Ghinassi   +6 more
doaj   +1 more source