Results 31 to 40 of about 407,893 (295)

Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro

iScience, 2022
Summary: Human fetal membrane mesenchymal stromal cells (hFM-MSCs) are a cell population easily isolable from the amniochorionic membrane of term placentas, without ethical issues or safety limitations.
Giulia Gaggi, Andrea Di Credico, Simone Guarnieri, Maria Addolorata Mariggiò, Patrizia Ballerini, Angela Di Baldassarre, Barbara Ghinassi   +6 more
doaj   +1 more source

Translational neuroscience measures of fear conditioning across development: applications to high-risk children and adolescents [PDF]

, 2013
Several mental illnesses, including anxiety, can manifest during development, with onsets in late childhood. Understanding the neurobiological underpinnings of risk for anxiety is of crucial importance for early prevention and intervention approaches ...
Kaitlyn L Gamwell, Karin Nylocks, Tanja Jovanovic   +2 more
core   +1 more source

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

iScience, 2020
Summary: Mammalian brain development critically depends on proper thyroid hormone signaling, via the TRα1 nuclear receptor. The downstream mechanisms by which TRα1 impacts brain development are currently unknown. In order to investigate these mechanisms,
Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant   +6 more
doaj   +1 more source

Selective postnatal excitation of neocortical pyramidal neurons results in distinctive behavioral and circuit deficits in adulthood

iScience, 2021
Summary: In genetic and pharmacological models of neurodevelopmental disorders, and human data, neural activity is altered within the developing neocortical network. This commonality begs the question of whether early enhancement in excitation might be a
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher I. Moore, Ute Hochgeschwender   +7 more
doaj   +1 more source

Better Vision Through Manipulation [PDF]

, 2002
For the purposes of manipulation, we would like to know what parts of the environment are physically coherent ensembles - that is, which parts will move together, and which are more or less independent.
Fitzpatrick, Paul, Metta, Giorgio
core   +5 more sources

KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner

iScience, 2022
Summary: A growing body of human literature implicates KIBRA in memory and neurodevelopmental disorders. Memory and the cellular substrates supporting adaptive cognition change across development.
Matthew L. Mendoza, Lilyana D. Quigley, Thomas Dunham, Lenora J. Volk   +3 more
doaj   +1 more source

Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents [PDF]

, 2011
Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to ...
B. J. Casey, Casey B. J., Eaton L. K., Epstein R., Haber S. N., Leah H. Somerville, Talairach J., Todd Hare   +7 more
core   +2 more sources

Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation

iScience, 2022
Summary: FBXO41 is a neuron-specific E3 ligase subunit implicated in epileptic encephalopathies. Fbxo41 null mutant (KO) mice show behavioral deficits and early lethality.
Ana R.A.A. Quadros, Rocío Díez Arazola, Andrea Romaguera Álvarez, Johny Pires, Rhiannon M. Meredith, Ingrid Saarloos, Matthijs Verhage, Ruud F. Toonen   +7 more
doaj   +1 more source

Social re-orientation and brain development: An expanded and updated view. [PDF]

, 2016
Social development has been the focus of a great deal of neuroscience based research over the past decade. In this review, we focus on providing a framework for understanding how changes in facets of social development may correspond with changes in ...
Guyer, Amanda E, Jarcho, Johanna M, Nelson, Eric E   +2 more
core   +2 more sources

Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior

iScience
Summary: Drinking and feeding are tightly coordinated homeostatic events and the paraventricular nucleus of the hypothalamus (PVH) represents a possible node of neural integration for signals related to energy and fluid homeostasis.
Serena R. Sweet, Jessica E. Biddinger, Jessie B. Zimmermann, Gina L. Yu, Richard B. Simerly   +4 more
doaj   +1 more source