Results 31 to 40 of about 1,182,997 (280)

Implications of the ABCD study for developmental neuroscience. [PDF]

Dev Cogn Neurosci, 2018
The Adolescent Brain Cognitive Development Study (ABCD) will capture a breadth of multi-faceted biobehavioral, environmental, familial, and genetic longitudinal developmental open-access data from over 11,000 9-10 year olds throughout the United States of America (USA) for an envisioned ten-year span.
Feldstein Ewing SW, Bjork JM, Luciana M.
europepmc   +4 more sources

16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis

iScience, 2022
Summary: The complex 16p11.2 deletion syndrome (16pdel) is accompanied by neurological disorders, including epilepsy, autism spectrum disorder, and intellectual disability. We demonstrated that 16pdel iPSC differentiated neurons from affected people show
Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour, Jasmine M. McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H. Futerman, Hazel Sive   +7 more
doaj   +1 more source

Development and cadherin-mediated control of prefrontal corticostriatal projections in mice

iScience, 2023
Summary: Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developing ...
Roxana E. Mesías, Yosif Zaki, Christopher A. Guevara, Lauren G. Friedman, Ayan Hussein, Karen Therrien, Alexandra R. Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G. Baxter, George W. Huntley, Deanna L. Benson   +11 more
doaj   +1 more source

Aberrant cortical projections to amygdala GABAergic neurons contribute to developmental circuit dysfunction following early life stress

iScience, 2023
Summary: Early life stress (ELS) results in enduring dysfunction of the corticolimbic circuitry, underlying emotional and social behavior. However, the neurobiological mechanisms involved remain elusive.
Joni Haikonen, Jonas Englund, Shyrley Paola Amarilla, Zoia Kharybina, Alexandra Shintyapina, Kristel Kegler, Marta Saez Garcia, Tsvetomira Atanasova, Tomi Taira, Henrike Hartung, Sari E. Lauri   +10 more
doaj   +1 more source

Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain

iScience, 2022
Summary: After demyelinating insult, the neuronal progenitors of the adult mouse sub-ventricular zone (SVZ) called neuroblasts convert into oligodendrocytes that participate to the remyelination process.
Bilal El Waly, Claire Bertet, Mathilde Paris, Marie Falque, Pierre Milpied, Karine Magalon, Myriam Cayre, Pascale Durbec   +7 more
doaj   +1 more source

Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates [PDF]

, 2017
This is the peer-reviewed but unedited manuscript version of the following article: Lee, W. L. A., et al. (2017). "Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates." Developmental Neuroscience 39(1-4): 49-58.
Wei Ling Amelia Lee, Adina T. Michael-Titus, Lee, WLA, Shah, DK, Michael-Titus, AT, Divyen K. Shah   +5 more
core   +1 more source

Interoception and psychopathology: A developmental neuroscience perspective. [PDF]

Dev Cogn Neurosci, 2017
Interoception refers to the perception of the physiological condition of the body, including hunger, temperature, and heart rate. There is a growing appreciation that interoception is integral to higher-order cognition. Indeed, existing research indicates an association between low interoceptive sensitivity and alexithymia (a difficulty identifying one'
Murphy J, Brewer R, Catmur C, Bird G.
europepmc   +7 more sources

Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation

iScience, 2022
Summary: FBXO41 is a neuron-specific E3 ligase subunit implicated in epileptic encephalopathies. Fbxo41 null mutant (KO) mice show behavioral deficits and early lethality.
Ana R.A.A. Quadros, Rocío Díez Arazola, Andrea Romaguera Álvarez, Johny Pires, Rhiannon M. Meredith, Ingrid Saarloos, Matthijs Verhage, Ruud F. Toonen   +7 more
doaj   +1 more source

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

iScience, 2020
Summary: Mammalian brain development critically depends on proper thyroid hormone signaling, via the TRα1 nuclear receptor. The downstream mechanisms by which TRα1 impacts brain development are currently unknown. In order to investigate these mechanisms,
Sabine Richard, Romain Guyot, Martin Rey-Millet, Margaux Prieux, Suzy Markossian, Denise Aubert, Frédéric Flamant   +6 more
doaj   +1 more source

Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

iScience, 2021
Summary: N6-methyladenosine (m6A) is emerging as a vital factor regulating neural differentiation. Here, we report that deficiency of Arhgef2, a novel cause of a neurodevelopmental disorder we identified recently, impairs neurogenesis, neurite outgrowth,
Pei Zhou, Yifei Qi, Xiang Fang, Miaomiao Yang, Shuxin Zheng, Caihua Liao, Fengying Qin, Lili Liu, Hong Li, Yan Li, Ethiraj Ravindran, Chuanbo Sun, Xinshu Wei, Wen Wang, Liang Fang, Dingding Han, Changgeng Peng, Wei Chen, Na Li, Angela M. Kaindl, Hao Hu   +20 more
doaj   +1 more source