Results 211 to 220 of about 25,080 (259)

Biomarkers of adult and developmental neurotoxicity

Toxicology and Applied Pharmacology, 2005
Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical, or physical agent. A multidisciplinary approach is necessary to assess adult and developmental neurotoxicity due to the complex and diverse functions of the nervous system.
William, Slikker, John F, Bowyer
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DEVELOPMENTAL CONSIDERATIONS OF NEUROTOXIC EXPOSURES

Neurologic Clinics, 2000
In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed.
C L, Trask, B E, Kosofsky
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Developmental neurotoxicity of polybrominated biphenyls

Neurotoxicology and Teratology, 1994
Female F0 generation Sprague-Dawley rats received daily oral doses of 0, 0.2, or 2 mg/kg polybrominated biphenyls (PBB) as fireMaster BP-6 from Day 6 of gestation through Day 24 postpartum. Maternal parameters were assessed, and F1 generation offspring were evaluated for growth and survival, as well as physical and behavioral development.
J W, Henck, J L, Mattsson, D H, Rezabek, C L, Carlson, R H, Rech   +4 more
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Bromate: Concern for developmental neurotoxicity?

Toxicology, 2006
The use of ozonation in the purification of drinking water can lead to the formation of bromate. The current regulatory challenges for bromate contamination of drinking water include the need to assess potential human health risks. One health risk of concern is developmental neurotoxicity. Currently, the need for a developmental neurotoxicity study for
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Biomarkers of Developmental Neurotoxicity

1992
Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical or physical agent. Neurotoxic effects may be permanent or reversible, produced by neuropharmacological or neurodegenerative properties of a neurotoxicant, or the result of direct or indirect actions ...
Andrew C. Scallet, William Slikker
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Design of a Primary Screen for Developmental Neurotoxicity

Toxicology and Industrial Health, 1989
A battery of tests was devised for routine use as a primary screen for developmental neurotoxicity. The battery was divided into pre-weaning and postweaning tests using rats as subjects. Since the rat CNS is structurally incomplete at birth, preweaning tests were predominantly physical, using specific landmarks of somatic maturation and regional brain ...
R F, Walker, F J, Guerriero, P J, Wier
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Neurospheres as a Model for Developmental Neurotoxicity Testing

2011
Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat to human health. So far, DNT testing is performed in animals. Such in vivo testing is time-consuming, expensive, and uses large numbers of animals. Moreover, species differences (rat-human) bear the problem of extrapolation.
Ellen, Fritsche, Kathrin, Gassmann, Timm, Schreiber   +2 more
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Editorial: Developmental neurotoxicity

Toxicology and Applied Pharmacology, 2018
Anna, Bal-Price, Ellen, Fritsche
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In Vitro Biomarkers of Developmental Neurotoxicity

2011
Magdalini Sachana, John Flaskos, Alan J. Hargreaves   +2 more
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Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity

International Journal of Molecular Sciences, 2021
Megan Chesnut, Helena T Hogberg, David Pamies   +2 more
exaly