Results 211 to 220 of about 23,637 (256)
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DEVELOPMENTAL CONSIDERATIONS OF NEUROTOXIC EXPOSURES
Neurologic Clinics, 2000In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed.
C L, Trask, B E, Kosofsky
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Developmental neurotoxicity of polybrominated biphenyls
Neurotoxicology and Teratology, 1994Female F0 generation Sprague-Dawley rats received daily oral doses of 0, 0.2, or 2 mg/kg polybrominated biphenyls (PBB) as fireMaster BP-6 from Day 6 of gestation through Day 24 postpartum. Maternal parameters were assessed, and F1 generation offspring were evaluated for growth and survival, as well as physical and behavioral development.
J W, Henck +4 more
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Bromate: Concern for developmental neurotoxicity?
Toxicology, 2006The use of ozonation in the purification of drinking water can lead to the formation of bromate. The current regulatory challenges for bromate contamination of drinking water include the need to assess potential human health risks. One health risk of concern is developmental neurotoxicity. Currently, the need for a developmental neurotoxicity study for
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Developmental Neurotoxicity of Chlorpyrifos: Cellular Mechanisms
Toxicology and Applied Pharmacology, 1995Chlorpyrifos, one of the most widely used pesticides, exhibits greater toxicity during development than in adulthood. We administered chlorpyrifos to neonatal rats in apparently subtoxic doses that caused no mortality and little or no weight deficits and examined developing brain regions (cerebellum, forebrain, brainstem) for signs of interference with
K D, Whitney, F J, Seidler, T A, Slotkin
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Biomarkers of Developmental Neurotoxicity
1992Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical or physical agent. Neurotoxic effects may be permanent or reversible, produced by neuropharmacological or neurodegenerative properties of a neurotoxicant, or the result of direct or indirect actions ...
Andrew C. Scallet, William Slikker
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Neurospheres as a Model for Developmental Neurotoxicity Testing
2011Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat to human health. So far, DNT testing is performed in animals. Such in vivo testing is time-consuming, expensive, and uses large numbers of animals. Moreover, species differences (rat-human) bear the problem of extrapolation.
Ellen, Fritsche +2 more
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Editorial: Developmental neurotoxicity
Toxicology and Applied Pharmacology, 2018Anna, Bal-Price, Ellen, Fritsche
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In Vitro Biomarkers of Developmental Neurotoxicity
2011Magdalini Sachana +2 more
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Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity
International Journal of Molecular Sciences, 2021Megan Chesnut +2 more
exaly