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Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus. [PDF]
Deng L +7 more
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Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat. [PDF]
O'Shaughnessy KL +6 more
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Developmental Neurotoxicity: An Update
Journal of Neurosurgical Anesthesiology, 2019In the section of “Developmental Neurotoxicity: An Update” of the Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) symposium 2018 the speakers presented the current literature in translational and clinical research. Dr. Brambrink spoke about translational research in anesthetic neurotoxicity, beginning with discovery in the rodent model, then
Philipp J, Houck +4 more
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DEVELOPMENTAL NEUROTOXICITY TO METHAMPHETAMINES
Clinical and Experimental Pharmacology and Physiology, 1995SUMMARY1. To investigate the long‐term changes caused by amphetamines in the developing brain, we used both an in vivo and in vitro model of chronic fetal exposure to methamphetamine and related drugs.2. Offspring of rats, treated with either saline, 2 mg/kg twice a day (b.i.d.) or 10 mg/kg bid. methamphetamine throughout gestation, were examined at 30
A D, Weissman, S, Caldecott-Hazard
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Oligodendroglia in Developmental Neurotoxicity
NeuroToxicology, 2003The developing nervous system has been long recognized as a primary target for a variety of toxicants. To date, most efforts to understand the impact of neurotoxic agents on the brain have focused primarily on neurons and to a lesser degree astroglia as cellular targets.
Wenbin, Deng, Ronald D, Poretz
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Update on developmental anesthesia neurotoxicity
Current Opinion in Anaesthesiology, 2017(Curr Opin Anaesthesiol. 2017;30:337–342. doi: 10.1097/ACO.0000000000000461) For more than 60 years, the controversial association between anesthesia exposure in early postnatal life and behavioral or neurocognitive deficiency have been studied.
Vutskits, Laszlo, Davidson, Andrew
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Developmental Neurotoxicity of Lead
2017Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit ...
Samuel, Caito, Michael, Aschner
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Epigenetic mechanisms in developmental neurotoxicity
Neurotoxicology and Teratology, 2018The constant interplay between environment (including both exogenous and endogenous factors) and epigenome (defined as the combination of chromatin, its covalent modifications and noncoding RNAs) triggers epigenetic events that, by modulating gene expression, capture information about changes in the environment.
M, Raciti, S, Ceccatelli
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Developmental Neurotoxicity of Carbon Monoxide
1995The results of recent studies dealing with behavioral and electrophysiological dysfunctions induced in rat offspring by prenatal exposure to relatively mild CO concentrations (75 and 150 ppm) have been reviewed in the present paper. In particular, gestational exposure to CO produced the following behavioral changes: (i) reduction in the minimum ...
M. R. Carratu' +4 more
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Biomarkers of adult and developmental neurotoxicity
Toxicology and Applied Pharmacology, 2005Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical, or physical agent. A multidisciplinary approach is necessary to assess adult and developmental neurotoxicity due to the complex and diverse functions of the nervous system.
William, Slikker, John F, Bowyer
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