Results 191 to 200 of about 23,637 (256)

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants. [PDF]

Toxics
Kreutz A, Oyetade OB, Chang X, Hsieh JH, Behl M, Allen DG, Kleinstreuer NC, Hogberg HT.   +7 more
europepmc   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity. [PDF]

Neurotoxicology
Collins ES, Hessel EVS, Hughes S.
europepmc   +1 more source

Developmental and Behavioral Effects of Arsenobetaine in Zebrafish (Danio rerio)

Journal of Applied Toxicology, EarlyView.
ABSTRACT Arsenobetaine (AsB) is a prevalent organoarsenical in aquatic environments and is generally regarded as nontoxic. Despite its widespread occurrence, the developmental and neurobehavioral toxicity of AsB has not been systematically investigated.
Sravan Kumar Putnala, Prerita Sharma, Prannav Jain, Samira Leila Baldin, Owen Luo, A. K. M. Munzurul Hasan, Md Helal Uddin, Mahesh Rachamalla, Som Niyogi   +8 more
wiley   +1 more source

Developmental neurotoxicity (DNT) QSAR combination prediction model establishment and structural characteristics interpretation. [PDF]

Toxicol Res (Camb)
Zhang L, Li M, Zhang D, Zhang S, Zhang L, Wang X, Qian Z.   +6 more
europepmc   +1 more source

Delivery Routes and Anesthesia Affect Cord Blood NGF, BDNF, and Neonatal Outcomes

Journal of Clinical Laboratory Analysis, EarlyView.
Nerve growth factor (NGF) and brain‐derived neurotrophin (BDNF) play a role in brain maturation. Cord blood values do not differ between vaginal delivery and CS cases. In CS cases with spinal anesthesia, high BDNF and NGF values were associated with high cord blood pH and APGAR scores.
Şükran Doğru, Huriye Ezveci, Fikriye Karanfil Yaman, Pelin Bahçeci, Zeynep Şenol, İbrahim Kılınç, Kazım Gezginç   +6 more
wiley   +1 more source

Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity. [PDF]

Cell Biosci
Wang G, Liu HY, Meng XW, Chen Y, Zhao WM, Li WT, Xu HB, Peng K, Ji FH.   +8 more
europepmc   +1 more source

Boosting Microglial Lipid Metabolism via TREM2 Signaling by Biomimetic Nanoparticles to Attenuate the Sevoflurane-Induced Developmental Neurotoxicity. [PDF]

Adv Sci (Weinh)
Li W, Meng X, Peng K, Han Y, Liu H, Zhao W, Wang G, Deng L, Liu H, Li Z, Ji F.   +10 more
europepmc   +1 more source