Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
International Journal of Nanomedicine, 2023 Meimei Wang,1,* Zhenzhen Zhang,2,* Ning Sun,3 Baolin Yang,4 Jihao Mo,5 Daping Wang,2 Mingqin Su,1 Jian Hu,1 Miaomiao Wang,6 Lei Wang7,8 1Department of Pathophysiology, School of Basic Medical Science, Anhui Medical University, Hefei, Anhui ...
Wang M +9 more
doaj
Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes. [PDF]
, 2019 BackgroundMahi-mahi (Coryphaena hippurus) is a commercially and ecologically important fish species that is widely distributed in tropical and subtropical waters.
Benetti, Daniel D +11 more
core +2 more sources
Expression classifiers for developmental toxicants
EXCLI journal, 2015 EXCLI Journal; 14:Doc1291; ISSN 1611 ...
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Distal Mentoring: An Antidote to Toxicity? [PDF]
International Journal of Evidence Based Coaching and Mentoring, 2013 Failures in mentoring relationships threaten outcomes and can lead to chronic damage to participants. This paper reports on findings from a recent doctoral study to establish how a developmental mentoring model would impact toxicity.
Rhianon Washington
doaj
International Journal of Nanomedicine, 2023 Wang M, Zhang Z, Sun N, et al. Int J Nanomedicine. 2023;18:1659—1676. The authors have advised the affiliation list on page 1659 is incorrect. The correct author list and affiliation is as follows.
Wang M +9 more
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Scientific Opinion on Flavouring Group Evaluation 7, Revision 5 (FGE.07Rev5) : saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5 [PDF]
, 2017 Acknowledgements: The Panel wishes to thank the members of the Working Group on Flavourings: Ulla Beckman Sundh, Leon Brimer, Karl-Heinz Engel, Paul Fowler, Rainer Gürtler, Trine Husøy, Wim Mennes and Gerard Mulder for the preparatory work on this ...
Anastassiadou, Maria +25 more
core +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Hexabromocyclododecane and hexachlorocyclohexane: How lessons learnt have led to improved regulation [PDF]
, 2014 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2014 Taylor & Francis.The use of chemicals by society has many benefits but contamination of the environment is an unintended consequence.
BSEF +14 more
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