Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Nature Medicine, 2021 Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens ...
Sarthak Sinha +2 more
exaly +2 more sources
INDEX study: intravenous dexamethasone palmitate for prophylaxis of postoperative nausea and vomiting: a study protocol for a randomised controlled study [PDF]
BMJ OpenIntroduction Dexamethasone is commonly used to prevent postoperative nausea and vomiting (PONV). However, PONV is an unresolved complex problem; even with preoperative dexamethasone administration, 14.0%–26.3% of patients undergoing minimally invasive ...
Hao Ren +5 more
doaj +2 more sources
Advanced Biomedical ResearchBackground: Common complications including stridor, laryngospasm, and bronchospasm are important in patients undergoing general anesthesia. Dexamethasone, lidocaine, and ketamine could have significant roles in reducing these complications. Here we aimed
Morteza Heidari +3 more
doaj +3 more sources
The Effect of the Timing of Dexamethasone Administration in Patients with COVID-19 Pneumonia [PDF]
Tuberculosis and Respiratory Diseases, 2021 Background Despite the proven benefits of dexamethasone in hospitalized coronavirus disease 2019 (COVID-19) patients, the optimum time for the administration of dexamethasone is unknown.
Hyun Woo Lee +4 more
doaj +1 more source
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.
New England Journal of Medicine, 2023 BACKGROUND Daratumumab, a monoclonal antibody targeting CD38, has been approved for use with standard myeloma regimens. An evaluation of subcutaneous daratumumab combined with bortezomib, lenalidomide, and dexamethasone (VRd) for the treatment of ...
P. Sonneveld +42 more
semanticscholar +1 more source
Acute Activation of Metabolic Syndrome Components in Pediatric Acute Lymphoblastic Leukemia Patients Treated with Dexamethasone. [PDF]
PLoS ONE, 2016 Although dexamethasone is highly effective in the treatment of pediatric acute lymphoblastic leukemia (ALL), it can cause serious metabolic side effects.
Lidewij T Warris +9 more
doaj +1 more source
Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report
medRxiv, 2020 Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death.
P. Horby +25 more
semanticscholar +1 more source
Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]
PLoS ONE, 2018 INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
doaj +1 more source