Results 11 to 20 of about 496,062 (355)

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

New England Journal of Medicine, 2020
Background Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.
P. Horby, W. Lim, J. Emberson, M. Mafham, Jennifer L Bell, Louise Linsell, N. Staplin, C. Brightling, A. Ustianowski, E. Elmahi, B. Prudon, C. Green, T. Felton, D. Chadwick, K. Rege, C. Fegan, L. Chappell, S. Faust, T. Jaki, K. Jeffery, A. Montgomery, K. Rowan, Edmund Juszczak, J. Baillie, R. Haynes, M. Landray   +25 more
semanticscholar   +1 more source

Efficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss

Drug Delivery, 2022
Dexamethasone sodium phosphate (Dex-SP) is the most commonly used drug administered via intratympanic injection for the treatment of acute hearing loss, but its penetration efficiency into the inner ear is very low.
So-Young Jung, Subin Kim, Zion Kang, Soonmin Kwon, Juhye Lee, Joo Won Park, Kab Sig Kim, Dong-Kee Kim   +7 more
doaj   +1 more source

Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients.
B. Tomazini, I. Maia, A. Cavalcanti, O. Berwanger, R. Rosa, V. Veiga, Á. Avezum, R. Lopes, F. Bueno, M. V. A. O. Silva, F. P. Baldassare, E. Costa, R. A. B. Moura, M. O. Honorato, A. N. Costa, L. Damiani, T. Lisboa, Letícia Kawano-Dourado, F. Zampieri, G. Olivato, C. Righy, C. P. Amêndola, R. Roepke, D. H. M. Freitas, D. N. Forte, F. G. Freitas, C. Fernandes, L. Melro, Gedealvares F S Junior, Douglas Costa Morais, S. Zung, F. Machado, L. Azevedo   +32 more
semanticscholar   +1 more source

Influence of Immune Status on the Airborne Colonization of Piglets with Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Complex (CC) 398 [PDF]

, 2020
Colonized vertebrates including humans and pigs are to date the main reservoirs of livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA). Currently, the mechanisms underlying colonization of pigs are not fully understood.
Ebner, Friederike, Friese, Anika, Hartmann, Susanne, Merle, Roswitha, Roesler, Uwe, Rosen, Kerstin, Schmidt, Stefanie   +6 more
core   +1 more source

The effect of dilution with glucose and prolonged injection time on dexamethasone-induced perineal irritation – A randomized controlled trial

Open Medicine, 2022
Dexamethasone can be used to prevent nausea and vomiting after surgery, but there is concern that it may induced perineal irritation. The aim of this study was to investigate the attenuation effect of dilution and slow injection on dexamethasone-induced ...
Zhang Yonghai, Liang Hong, Huang Liwei, Zheng Junwei, Chen Yi, Li Bin, Yang Fan, Yu Jingfang, Ma Hanxiang   +8 more
doaj   +1 more source

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion

Science Advances, 2022
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as ...
Anne von Mässenhausen, Nadia Zamora Gonzalez, F. Maremonti, A. Belavgeni, W. Tonnus, C. Meyer, Kristina Beer, M. Hannani, A. Lau, M. Peitzsch, Paul Hoppenz, S. Locke, T. Chavakis, R. Kramann, D. Muruve, C. Hugo, S. Bornstein, A. Linkermann   +17 more
semanticscholar   +1 more source

The Effect of Dexamethasone Treatment on COVID-19 Prognosis in Cancer Patients

Vaccines, 2022
Background: Dexamethasone is used to treat cancer, relieve chemotherapy-induced nausea and vomiting, enhance cancer patients’ appetites, and treat COVID-19 patients. There is little evidence of the impact of a dexamethasone treatment plan on the severity
Lina Souan, Zienab Al-Khairy, Maysaa’ Adnan Al-Binni, Abdelkader Battah, Maher A. Sughayer   +4 more
doaj   +1 more source

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

Nature Network Boston, 2021
Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens ...
S. Sinha, Nicole L. Rosin, R. Arora, Elodie Labit, A. Jaffer, L. Cao, Raquel Farias, Angela P. Nguyen, Luiz G. N. de Almeida, A. Dufour, A. Bromley, B. McDonald, M. Gillrie, M. Fritzler, B. Yipp, J. Biernaskie   +15 more
semanticscholar   +1 more source

Baricitinib plus dexamethasone compared to dexamethasone for the treatment of severe COVID-19 pneumonia: A retrospective analysis

Journal of Microbiology, Immunology and Infection, 2021
Objective: We aimed to analyze clinical outcomes from patients with severe COVID-19 pneumonia that received either baricitinib plus dexamethasone or dexamethasone monotherapy. Methodology: We performed a retrospective comparative study.
Eduardo Pérez-Alba, Laura Nuzzolo-Shihadeh, Gloria Mayela Aguirre-García, Jaime Espinosa-Mora, Juan Diego Lecona-Garcia, Romulo Omar Flores-Pérez, Marisela Mendoza-Garza, Adrián Camacho-Ortiz   +7 more
doaj   +1 more source

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial.

Journal of the American Medical Association (JAMA), 2021
Importance A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease.
M. W. Munch, S. Myatra, B. Vijayaraghavan, S. Saseedharan, T. Benfield, R. R. Wahlin, B. Rasmussen, A. S. Andreasen, Lone M. Poulsen, L. Cioccari, M. Khan, F. Kapadia, J. Divatia, A. C. Brøchner, M. Bestle, M. Helleberg, J. Michelsen, Ajay Padmanaban, N. Bose, A. Møller, K. Borawake, K. T. Kristiansen, U. Shukla, M. Chew, S. Dixit, C. Ulrik, P. Amin, R. Chawla, C. Wamberg, Mehul Shah, I. S. Darfelt, V. Jørgensen, M. Smitt, A. Granholm, M. N. Kjær, M. Møller, T. Meyhoff, G. K. Vesterlund, N. Hammond, S. Micallef, Abhinav Bassi, Oommen John, Anubhuti Jha, M. Cronhjort, S. Jakob, C. Gluud, T. Lange, Vaijayanti Kadam, Klaus V. Marcussen, J. Hollenberg, A. Hedman, H. Nielsen, O. Schjørring, M. Q. Jensen, J. W. Leistner, T. Jonassen, C. M. Kristensen, Esben C. Clapp, C. J. Hjortsø, T. S. Jensen, Liv S. Halstad, Emilie R. B. Bak, Reem Zaabalawi, Matias Metcalf-Clausen, Suhayb Abdi, E. Hatley, Tobias S. Aksnes, Emil Gleipner-Andersen, Arif F. Alarcón, Gabriel Yamin, Adam Heymowski, Andreas Berggren, Kirstine N la Cour, Sarah Weihe, A. H. Pind, Janus Engstrøm, V. Jha, B. Venkatesh, A. Perner   +78 more
semanticscholar   +1 more source