Results 11 to 20 of about 63,586 (320)

Intraperitoneal Versus Intravenous Dexmedetomidine for Postoperative Analgesia Following Laparoscopic Sleeve Gastrectomy Surgery: A prospective, Randomized Controlled trial

Egyptian Journal of Anaesthesia, 2023
Background Postoperative pain control is a major challenge after laparoscopic sleeve gastrectomy. We conducted this study to evaluate the efficacy of dexmedetomidine either intraperitoneal (IP) or intravenous (IV) as an adjuvant to intraperitoneal ...
Asmaa Fawzy Amer, Tarek Abdel Hay Mostafa, Radwa Fathy Mansour   +2 more
doaj   +1 more source

Effect of dexmedetomidine on intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic lung lobectomy

Journal of Cardiothoracic Surgery, 2020
Background The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect.
Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji
doaj   +1 more source

Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke

Intensive Care Medicine Experimental, 2022
Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation.
Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi, Patricia Rieken Macedo Rocco   +12 more
doaj   +1 more source

Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Frontiers in Aging Neuroscience, 2022
Background: Inflammation promotes the progression of Alzheimer’s disease (AD). In this study, we explored the effect of dexmedetomidine on inflammation and cognitive function in a mouse model of AD.Methods: 5xFAD mice were intragastrically administered ...
Su-mei Luo, Long-yan Li, Long-yan Li, Li-zhe Guo, Lu Wang, Yan-feng Wang, Na Chen, E. Wang, E. Wang   +8 more
doaj   +1 more source

Effect of dexmedetomidine on the Montreal Cognitive Assessment in older patients undergoing pulmonary surgery

Journal of International Medical Research, 2022
Objective We investigated the effect of dexmedetomidine anesthesia on postoperative cognitive function after pulmonary surgery. Methods A blinded, prospective, randomized, placebo-controlled study was performed on 60 patients (age range 65–74 years ...
Tao Liu, Fang-Chao Liu, Yu Xia, Tai-Jun Luo, Fei Wang, Bin Chen, Chun Wang, Guang-Kuo Gao, Wen-Ting Zhai, Wei Liu   +9 more
doaj   +1 more source

The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review

Brain Science, 2021
Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely used clinically for sedation and anesthesia. The role of dexmedetomidine has been an interesting topic of neonatological and anesthetic research since a series of ...
Zaara Liaquat, Xiaoying Xu, X XX XXXXX, R. Fu, Lihua Zhou   +4 more
semanticscholar   +1 more source

Recent Advances in the Clinical Value and Potential of Dexmedetomidine

Journal of Inflammation Research, 2021
Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic, analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative response which shows an easy transition from sleep to wakefulness, thus allowing ...
Xiaotian Liu, Yueqin Li, Li Kang, Qian Wang   +3 more
semanticscholar   +1 more source

Comparison of dexmedetomidine alone or with other sedatives for paediatric sedation during magnetic resonance imaging: a systematic review [PDF]

Medicinski Glasnik, 2023
Aim To compare the outcome of sole dexmedetomidine or with other sedative drugs in paediatric patients during magnetic resonance imaging (MRI). Methods Literature was obtained from PubMed and ScienceDirect from 2010-2020 using key words: sedation ...
Rudy Vitraludyono, Arie Utariani, Elizeus Hanindito   +2 more
doaj   +1 more source

The effect of peri‐operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non‐cardiac surgical patients: a randomised, double‐blind placebo‐controlled trial

Anaesthesia, 2021
Delirium occurs commonly following major non‐cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative complications and morbidity ...
J. van Norden, C. Spies, F. Borchers, M. Mertens, J. Kurth, J. Heidgen, A. Pohrt, A. Mueller   +7 more
semanticscholar   +1 more source

Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats [PDF]

International Neurourology Journal, 2017
Purpose Dexmedetomidine, an α2-adrenergic agonist, provides sedative and analgesic effects without significant respiratory depression. Dexmedetomidine has been suggested to have an antiapoptotic effect in response to various brain insults.
Je Hoon Park, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Chang Ju Kim, Soo Hwan Yoon, Jongki Hong, Jun Young Chung, Deok Won Lee   +9 more
doaj   +1 more source