Results 201 to 210 of about 69,499 (314)

Protocol for a multicentre, prospective cohort study of practice patterns and clinical outcomes associated with emergency department sedation for mechanically ventilated patients: The ED-SED Study [PDF]

, 2018
Avidan, Michael S, Carpenter, Christopher R, Fuller, Brian M, Kollef, Marin H, Mohr, Nicholas M, Roberts, Brian W   +5 more
core   +1 more source

Enhancing Caudal Analgesia in Children: A Narrative Review of Clonidine and Dexmedetomidine as Adjuvants. [PDF]

Cureus
Vaswani A, Bairwa K, Kewalramani R, Gangani J, Mohan V.   +4 more
europepmc   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, Volume 13, Issue 2, 9 January 2026.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Effects of perioperative dexmedetomidine on renal vascular function and renovascular histopathology in ovine cardiopulmonary bypass. [PDF]

Intensive Care Med Exp
Betrie AH, Jufar AH, Evans RG, Cochrane AD, Marino B, Birchall I, Hood SG, McCall PR, Ayton S, Miles LF, May CN, Lankadeva YR.   +11 more
europepmc   +1 more source

Effects of Dexmedetomidine on the Behavioral Outcomes in Streptozotocin‐Induced Alzheimer's Disease Rats

Brain and Behavior, Volume 16, Issue 1, January 2026.
Dexmedetomidine at 25 µg/kg effectively reverses working and spatial memory deficits in a streptozotocin (STZ)‐induced rat model of Alzheimer's disease, restoring Y‐maze alternation and Morris Water Maze performance. Higher doses show no clear benefit, highlighting Dex‐25 as a promising neuroprotective candidate.
Mina Mohasel‐Roodi, Masoumeh Nozari, Ali Shamsara, Mohsen Basiri, Vida Mirzaie, Masoumeh Baghalishahi   +5 more
wiley   +1 more source

A Regional Approach to a Global Challenge: A Case Report of Caudal Anesthesia for Anoplasty in Tetralogy of Fallot With Pulmonary Atresia

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Timeline of the patient's clinical course from birth to follow‐up: (birth, diagnosis, NICU admission, prostaglandin infusion, surgery date, post‐op NICU stay, discharge and 3 month follow‐up). ABSTRACT Patients with Tetralogy of Fallot (TOF) with pulmonary atresia present high perioperative risks during non‐cardiac surgeries, making anesthetic ...
Prince Barnawal, Rukesh Yadav, Sandeep Khatri, Jyoti K. C. Khatri, Sudarshan Acharya   +4 more
wiley   +1 more source

Dexmedetomidine Versus Clonidine as an Adjuvant to Lidocaine Spinal Anesthesia in an Ovine Experimental Model. [PDF]

Animals (Basel)
Piemontese C, Vicenti C, Crovace AM, Pizzi R, Stabile M, Guadalupi M, Lacitignola L, Staffieri F.   +7 more
europepmc   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

Meta-analysis of the sedative effects of midazolam and dexmedetomidine in patients undergoing bronchoscopy. [PDF]

Am J Clin Exp Immunol
Kong C, Wang L, Zhong T, Deng F, Zhang F.   +4 more
europepmc   +1 more source

Efficacy of Dexmedetomidine as an Adjuvant to Bupivacaine in UltrasoundGuided Transverse Abdominis plane Block for Laparoscopic appendicectomy: A Randomised Controlled Study

, 2019
Soma Ganesh Raja Neethirajan, Santoshi Kurada, Aruna Parameswari   +2 more
openalex   +1 more source