Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol, methadone, morphine or tramadol in conscious sheep [PDF]
, 2016 Objective: To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol, methadone, morphine or tramadol in healthy sheep. Study design: Randomized crossover study. Animals: Six Santa Inês
Auckburally, Adam +5 more
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Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study [PDF]
Korean Journal of Anesthesiology, 2017 BackgroundDexmedetomidine is a highly selective central α2-agonist used as a sedative in pediatric intensive care unit (PICU). However, little is known about the relationship between dexmedetomidine dose and its plasma concentration during long-term ...
Yoshihito Fujita +6 more
doaj +1 more source
Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia
Frontiers in Neuroscience, 2022 Dexmedetomidine, as an α2-adrenoceptor agonist, plays anti-sympathetic, sedative and analgesic roles in perioperative period. Also, dexmedetomidine can reduce the minimal alveolar concentration (MAC) of sevoflurane and the risk of postoperative cognitive
Lei Zhang +15 more
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Risk Factors of Intraoperative Dysglycemia in Elderly Surgical Patients [PDF]
, 2019 BACKGROUNDː Dysglycemia is associated with adverse outcome including increased morbidity and mortality in surgical patients. Acute insulin resistance due to the surgical stress response is seen as a major cause of so-called stress hyperglycemia. However,
Knaak, Cornelia +8 more
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α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury [PDF]
, 2016 Renal ischemia-reperfusion (rI/R) could cause remote acute lung injury (ALI) and combination of these two organ injuries can remarkably increase the mortality.
Chen, Q +7 more
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Journal of Intensive Care, 2019 Purpose Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking.
Ekaterina R. Yavarovich +4 more
doaj +1 more source
A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]
, 2013 Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M. +3 more
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Frontiers in PharmacologyAimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2016 Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia.
Maiko Hongo +6 more
doaj +1 more source
Dexmedetomidine does not produce vasocontraction on human isolated gastroepiploic artery [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundRecently, the addition of dexmedetomidine to sedation regimens after cardiac surgery had been reported and there is a possibility that dexmedetomidine can cause vasoconstriction.
Won-Sung Kim +5 more
doaj +1 more source