Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation [PDF]
, 2019 Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation.
Allegaert, Karel +8 more
core +5 more sources
Patient Safety in Surgery, 2020 Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in ...
Mohammad Reza Fazel +3 more
doaj +1 more source
Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol, methadone, morphine or tramadol in conscious sheep [PDF]
, 2016 Objective: To compare cardiopulmonary and sedative effects following administration of dexmedetomidine alone or with butorphanol, methadone, morphine or tramadol in healthy sheep. Study design: Randomized crossover study. Animals: Six Santa Inês
Auckburally, Adam +5 more
core +1 more source
α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury [PDF]
, 2016 Renal ischemia-reperfusion (rI/R) could cause remote acute lung injury (ALI) and combination of these two organ injuries can remarkably increase the mortality.
Chen, Q +7 more
core +3 more sources
Risk Factors of Intraoperative Dysglycemia in Elderly Surgical Patients [PDF]
, 2019 BACKGROUNDː Dysglycemia is associated with adverse outcome including increased morbidity and mortality in surgical patients. Acute insulin resistance due to the surgical stress response is seen as a major cause of so-called stress hyperglycemia. However,
Knaak, Cornelia +8 more
core +1 more source
Journal of Intensive Care, 2019 Purpose Alcohol withdrawal syndrome (AWS) is commonly treated in medical ICUs and typically requires high resource utilization. Dexmedetomidine for AWS has not been extensively investigated, and guidelines regarding its use are lacking.
Ekaterina R. Yavarovich +4 more
doaj +1 more source
Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care [PDF]
, 2018 There is growing evidence both in the perioperative period and in the field of intensive care (ICU) on the association between left ventricular diastolic dysfunction (LVDD) and worse outcomes in patients.
Morelli, A. +3 more
core +1 more source
A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice [PDF]
, 2013 Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents.
Burnside, Wesley M. +3 more
core +3 more sources
Frontiers in PharmacologyAimTo compare the effects of midazolam, propofol, and dexmedetomidine monotherapy and combination therapy on the prognosis of intensive care unit (ICU) patients receiving continuous mechanical ventilation (MV).Methods11,491 participants from the Medical ...
Xiaoding Shi +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2016 Dexmedetomidine is a selective α2 adrenergic agonist. Although dexmedetomidine is widely used for sedation and analgesia, it frequently produces hypotension and bradycardia.
Maiko Hongo +6 more
doaj +1 more source