Results 41 to 50 of about 63,586 (320)
Oxidative Medicine and Cellular Longevity, 2021 Background Perinatal hypoxia is a universal cause of death and neurological deficits in neonates worldwide. Activation of microglial NADPH oxidase 2 (NOX2) leads to oxidative stress and neuroinflammation, which may contribute to hypoxic damage in the ...
Xiaohui Chen +7 more
semanticscholar +1 more source
BMC Anesthesiology, 2020 Background Sepsis often accompanies gastrointestinal motility disorder that contributes to the development of sepsis in turn. Propofol and dexmedetomidine, as widely used sedatives in patients with sepsis, are likely to depress gastrointestinal ...
Haiqing Chang +9 more
doaj +1 more source
Mechanisms of Dexmedetomidine in Neuropathic Pain
Frontiers in Neuroscience, 2020 Dexmedetomidin is a new-generation, highly selective α2 adrenergic receptor agonist with a large number of advantages, including its sedative and analgesic properties, its ability to inhibit sympathetic nerves, its reduced anesthetic dosage, its ...
Yang Zhao +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Background and Purpose: There are many benefits of administering dexmedetomidine perioperatively. The pharmacokinetics (PK) and pharmacodynamics (PD) of intravenous, intranasal and oral dexmedetomidine that was administered before anesthesia were ...
Jinhong Wu +5 more
doaj +1 more source
Animals, 2021 Simple Summary Dexmedetomidine, on account of its potent sedative and analgesic properties, is commonly used in balanced anesthesia of small animal anesthesia; however, concerns regarding its cardiovascular effects prevent its full adoption into ...
S. Pan, Gang Liu, Jianwen Lin, Yi Jin
semanticscholar +1 more source
Journal of Inflammation Research, 2021 Background Endoplasmic reticulum stress (ERS)-mediated myocardial inflammation and apoptosis plays an important role in myocardial ischemia/reperfusion (I/R) injury. Dexmedetomidine has been used clinically with sedative, analgesic, and anti-inflammatory
Yu-Fan Yang +9 more
semanticscholar +1 more source
Sedation and the potential application of dexmedetomidine: Sedation and dexmedetomidine
Serbian Journal of Anesthesia and Intensive Therapy, 2016 Minimal Sedation (Anxiolysis) is a drug-induced state during which patients respond normally to verbal commands. Although cognitive function and physical coordination may be impaired, airway reflexes, and ventilatory and cardiovascular functions are unaffected.
Nebojša Lađević +4 more
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Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia
Frontiers in Neuroscience, 2022 Dexmedetomidine, as an α2-adrenoceptor agonist, plays anti-sympathetic, sedative and analgesic roles in perioperative period. Also, dexmedetomidine can reduce the minimal alveolar concentration (MAC) of sevoflurane and the risk of postoperative cognitive
Lei Zhang +15 more
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British Journal of Surgery, 2020 Delirium is common in elderly patients after surgery and is associated with poor outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on the incidence of delirium in elderly patients undergoing major surgery.
C-J Li +7 more
semanticscholar +1 more source
Dexmedetomidine and delirium in the ICU [PDF]
Annals of Translational Medicine, 2016 Delirium is a common problem encountered in the care of critically ill patients. It is characterized by an acute onset of impaired cognitive functioning that has a fluctuating course with impairment in a patient’s ability to process information (1).
Matthew McLaughlin, Paul E. Marik
openaire +3 more sources