Results 61 to 70 of about 69,499 (314)

Dexmedetomidine hydrochloride as a long-term sedative

Therapeutics and Clinical Risk Management, 2011
Takayuki KunisawaSurgical Operation Department, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, JapanAbstract: Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory ...
Kunisawa T
doaj  

Research progress on the depth of anesthesia monitoring based on the electroencephalogram

Ibrain, Volume 11, Issue 1, Page 32-43, Spring 2025.
Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley   +1 more source

The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review

Brain Sciences, 2021
Dexmedetomidine, selective α2-adrenergic agonist dexmedetomidine, has been widely used clinically for sedation and anesthesia. The role of dexmedetomidine has been an interesting topic of neonatological and anesthetic research since a series of ...
Zaara Liaquat, Xiaoying Xu, Prince Last Mudenda Zilundu, Rao Fu, Lihua Zhou   +4 more
doaj   +1 more source

Safety of MRI Examinations Under Sedation: A Nationwide Survey in Japan

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MRI is performed under sedation for patients requiring immobility or for those already sedated for clinical management. Although specialist guidelines advocate for anesthesiologist‐led care, non‐anesthesiologist‐led adult sedation is a common practice worldwide. Furthermore, the increase in risk attributable to sedation has not been
Shiori Amemiya, Masako Kataoka, Tsukasa Doi, Toshinori Hirai, Takayuki Obata, Kagayaki Kuroda   +5 more
wiley   +1 more source

Evaluation of Brain Microstructural Alterations in Preschool Autism Spectrum Disorder: A Voxel‐Wise Multimodal MRI Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Autism Spectrum Disorder (ASD) presents with early neurodevelopmental alterations in preschool children, yet comprehensive characterization using multimodal quantitative MRI remains limited in this age group. Purpose To investigate voxel‐wise brain microstructural differences in preschool ASD through integrated analysis of cerebral ...
Changhao Wang, Meiying Cheng, Yu Lu, Jinxia Guo, Xueyan Liu, Zhanqi Feng, Shipeng Liu, Xin Zhao   +7 more
wiley   +1 more source

Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: A before-after study [PDF]

, 2015
INTRODUCTION: Randomized controlled trials suggest clinical outcomes may be improved with dexmedetomidine as compared to benzodiazepines, however further study and validation is needed.
Boyle, Walter A, Drewry, Anne M, Fagley, Richard E, Field, R. Ryan, Kollef, Marin H, Lieu, Angela, Micek, Scott T, Olatunde, Joshua, Skrupky, Lee P, Varghese, Linda, Wessman, Brian   +10 more
core   +2 more sources

Epicutaneo‐caval catheter occlusion in neonates without heparin infusion during parenteral nutrition: A descriptive cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Heparin is frequently infused in neonatal central venous catheters to prevent occlusion during parenteral nutrition despite limited evidence of its effectiveness and potential safety concerns in preterm infants. This study evaluated the incidence of catheter occlusion in epicutaneo‐caval catheters managed without heparin in a large ...
Vito D'Andrea, Giorgia Prontera, Cecilia Monachini, Micaela Cerreti, Francesca Baldo, Giovanni Barone, Giovanni Vento   +6 more
wiley   +1 more source

Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness [PDF]

, 2014
Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness.
Akeju, Oluwaseun, Arabasz, Grae, Brown, Emery N, Catana, Ciprian, Chonde, Daniel B, Contreras Ramirez, Violeta, Habeeb, Kathleen, Hooker, Jacob M, Hsu, Shirley, Izquierdo-Garcia, David, Loggia, Marco L, Napadow, Vitaly, Pavone, Kara J, Purdon, Patrick L, Rhee, James, Vazquez, Rafael   +15 more
core   +3 more sources

Intraoperative dexmedetomidine-induced polyuria from a loading dose: a case report

Journal of International Medical Research, 2020
With extensive perioperative use of dexmedetomidine, there has been rising concern about its side effects, which are most commonly bradycardia and hypotension.
Zhang Chen, Ting Chen, Haiwang Ye, Junping Chen, Bo Lu   +4 more
doaj   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source