Results 71 to 80 of about 63,586 (320)

Recent applications of magnetic iron oxide nanoparticles for cerebral blood volume quantification in functional magnetic resonance imaging

Ibrain, EarlyView.
This study explores the recent advances in the use of iron oxide nanoparticles (IONPs) in functional MRI (fMRI) for studying brain functions, specifically cerebral blood volume (CBV) measurements. It covers fMRI techniques, magnetic nanoparticle synthesis, coating methods, and their applications in CBV imaging, in comparison to other contrast agents in
Giorgio Capuzzello, Antonella Antonelli, Rosaria Rinaldi, Riccardo Di Corato   +3 more
wiley   +1 more source

Safety of MRI Examinations Under Sedation: A Nationwide Survey in Japan

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MRI is performed under sedation for patients requiring immobility or for those already sedated for clinical management. Although specialist guidelines advocate for anesthesiologist‐led care, non‐anesthesiologist‐led adult sedation is a common practice worldwide. Furthermore, the increase in risk attributable to sedation has not been
Shiori Amemiya, Masako Kataoka, Tsukasa Doi, Toshinori Hirai, Takayuki Obata, Kagayaki Kuroda   +5 more
wiley   +1 more source

Dexmedetomidine hydrochloride as a long-term sedative

Therapeutics and Clinical Risk Management, 2011
Takayuki KunisawaSurgical Operation Department, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, JapanAbstract: Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory ...
Kunisawa T
doaj  

Effects of dexmedetomidine on surgery for type A acute aortic dissection outcome

Scientific Reports, 2022
No study has evaluated the effect of dexmedetomidine in patients who received surgery for type A aortic dissection. This is the first study to evaluate the effect of dexmedetomidine in aortic dissection patients.
Yu-Ting Cheng, Kuang-Tso Lee, Chih-Hsiang Chang, Victor Chien-Chia Wu, Yi-Shin Chan, Dong-Yi Chen, Pao-Hsien Chu, An-Hsun Chou, Kuo-Sheng Liu, Shao-Wei Chen   +9 more
doaj   +1 more source

Dexmedetomidine Improves Cardiovascular and Ventilatory Outcomes in Critically Ill Patients: Basic and Clinical Approaches

Frontiers in Pharmacology, 2020
Dexmedetomidine (DEX) is a highly selective α2-adrenergic agonist with sedative and analgesic properties, with minimal respiratory effects. It is used as a sedative in the intensive care unit and the operating room.
R. Castillo, Mauricio Ibacache, I. Cortínez, Catalina Carrasco-Pozo, J. Farías, R. Carrasco, Patricio Vargas-Errázuriz, Daniel Ramos, R. Benavente, D. Torres, Aníbal Méndez   +10 more
semanticscholar   +1 more source

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Influence of Age on Fracture Healing in Young and Middle‐Aged Mice in a Proximal Femur Fracture Model

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Osteoporotic hip fractures are a considerable cause of pain and disability particularly among the elderly. Osteoporosis causes loss of bone stability, which in turn leads to an increased risk of fractures especially in metaphyseal bone. Moreover, the body′s capacity for healing is diminished, resulting in prolonged recovery times following ...
Tabea Schmid, Anna Kanewska, Charles Lam, Miriam Kalbitz, Sandra Dieterich, Anita Ignatius, Jana Riegger, Nico Valerio Giger, Esther Wehrle, Ralph S. Marcucio, Theodore Miclau, Melanie Haffner‐Luntzer   +11 more
wiley   +1 more source

Perbandingan Pemberian Dexmedetomidine dengan Fentanyl Intraoperatif terhadap Kedalaman Anestesia dan Kecepatan Pemulihan pada Operasi Bedah Saraf

Jurnal Neuroanestesi Indonesia, 2022
Latar Belakang dan Tujuan: Anestesi bebas opioid merupakan diskusi baru dalam dunia anestesi. Bukti menunjukkan bahwa opioid memiliki efek samping yang tidak diinginkan. Dexmedetomidine merupakan suatu reseptor agonis a2-adrenergik selektif yang memiliki
Zafrullah Kany Jasa, Teuku Heriansyah, Muttaqin Muttaqin   +2 more
doaj   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

Effect of intraoperative dexmedetomidine on renal function after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a randomized, placebo-controlled trial

International Journal of Hyperthermia, 2019
Introduction: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) predispose to postoperative renal dysfunction. Dexmedetomidine is an α2 adrenoreceptor agonist, which has renoprotective effects after cardiac surgery ...
Young Song, Do-Hyeong Kim, Tae Dong Kwon, Dong Woo Han, Seung Hyuk Baik, Hwan Ho Jung, Ji Young Kim   +6 more
doaj   +1 more source