Results 241 to 250 of about 78,284 (308)

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

Small, Volume 22, Issue 37, 2 July 2026.
This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang, Maximilian Wipplinger, Parastoo Akbarimoghaddam, Raquel Alonso‐Roman, Zoltan Cseresnyes, Axel Dietschmann, Valentin Wegner, Adrian Feile, Yann Bachelot, Maria Warschinke, Mohamed I. Abdelwahab Hassan, Sonnhild Mittag, Otmar Huber, Bernhard Hube, Mark S. Gresnigt, Marc Thilo Figge, Alexander S. Mosig   +16 more
wiley   +1 more source

Microvascular Damage in the Deep Mucosal <i>Lamina Propria</i> Triggers the Onset of Colitis in Dextran Sulfate Sodium-induced Colitis in Mice. [PDF]

In Vivo
Saijo H, Hashimoto H, Arihiro S, Kusakabe M, Okabe M.   +4 more
europepmc   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, Volume 56, Issue 7, Page 769-783, July 2026.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model. [PDF]

Cells
Figueroa-Gispert MDM, Ramos-Lugo CM, Ocasio-Malavé C, Scott RP, Ahrendsen JT, Gomez-Samblas M, Osuna A, Dorta-Estremera SM, Espino AM.   +8 more
europepmc   +1 more source

EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi‐Omics and Experimental Study

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
This study employed an integrated multi‐omics screening strategy incorporating GEO database differential expression analysis, GWAS‐eQTL genetic association analysis, and single‐cell RNA‐seq cell subpopulation localization to identify EPHX2 as a core causal gene in ulcerative colitis (UC).
Tian Dai, Siyu Han, Xiaoping Hu, Jiakuo Gu, Dongmei Liu, Jiale Wu, Juyan Zheng, Shiqin Hong, Yiwen Zhang   +8 more
wiley   +1 more source

Chrysin ameliorates dextran sulfate-induced ulcerative colitis in mice by modulating inflammation and gut microbiota. [PDF]

Int J Colorectal Dis
Yao X, Chen Y, Li Y, Mo J, Liu X, Wang P, Jia D, Li H, Guo C.   +8 more
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Dextran sulfate inhibits the invasion, migration, and programmed death-ligand 1 expression in human gastric cancer cells by affecting the M2 tumor-associated macrophage polarization. [PDF]

Front Oncol
Shang J, Xu Y, Tao Y, Li B, Li M, Guo J, Yan L, Huang Y, Ma Q.   +8 more
europepmc   +1 more source

Cellular Dynamics of Transgenic Porcine Endothelial Cells to Inflammatory Stimuli in Xenotransplantation Settings

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Inflammatory responses have been shown to contribute significantly to the rejection of grafts in both allo‐ and xenotransplantation. In particular, they play a pivotal role in promoting endothelial activation, complement deposition, and thrombosis, thereby compromising the graft function.
Mitra Gultom, Nina Thomi, Kassandra Teixeira‐Riberio, Jane Shaw, Alain Despont, Nikolai Klymiuk, Elisabeth Kemter, Eckhard Wolf, Robert Rieben   +8 more
wiley   +1 more source

Probiotic <i>Lacticaseibacillus paracasei</i> E10 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Enhancing the Intestinal Barrier and Modulating Microbiota. [PDF]

Foods
Dai Y, Lin Z, Zhang X, Wang Y, Sheng Y, Gao R, Geng Y, Xue Y, Ren Y.   +8 more
europepmc   +1 more source