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Network pharmacology and experimental validation reveal clotrimazole alleviates dextran sulfate sodium-induced ulcerative colitis by inhibiting intestinal senescence. [PDF]
Chen C +8 more
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Microvascular Damage in the Deep Mucosal <i>Lamina Propria</i> Triggers the Onset of Colitis in Dextran Sulfate Sodium-induced Colitis in Mice. [PDF]
Saijo H +4 more
europepmc +1 more source
Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice
The aim of this study is to assess the preventive effects of Lactobacillus fermentum HY01 (LF-HY01) to dextran sulfate sodium induced-colitis. We observed the ratio of colon weight to its length, colon pathological changes, and the concentrations of pro ...
Xin Zhao, Huayi Suo, Hongwei Wang
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Induction of Colitis in Young Rats by Dextran Sulfate Sodium
Digestive Diseases and Sciences, 2005Models using dextran sulfate sodium (DSS) to induce experimental colitis in rodents have been performed mostly in adult animals. For this reason, we aimed to develop a model of colitis in young rats. DSS was administered to 30-day-old rats at concentrations ranging from 0.5 to 5% in drinking water.
María, Vicario +5 more
openaire +3 more sources
Dextran Sulfate Sodium-Induced Colitis in Immunodeficient Rats
Digestive Diseases and Sciences, 2000To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dextran sulfate in drinking water for periods ranging from 3 to 60 days.
K, Shichijo +3 more
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Effect of Heparin on Dextran Sulfate Sodium-Induced Colitis
Digestive Diseases and Sciences, 1998Heparin has been shown to ameliorate inflammatory bowel disease in several series. In addition to its anticoagulant properties, heparin has numerous other effects that may be beneficial in inflammatory bowel disease. Other sulfated polysaccharides, such as dextran sulfate, cause colitis in mice through unknown mechanisms.
J R, Korzenik, A, Hsu, M E, Robert
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Digestive Diseases and Sciences, 2011
We hypothesized that the severity of dextran sodium sulfate (DSS)-induced colitis could differ between DSS preparations of the same molecular weight, and that this difference may be affected by the sulfur content. To test this, we used three DSS preparations of similar molecular weights but with different sulfur contents.Three DSS preparations with ...
Shigeki, Bamba +14 more
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We hypothesized that the severity of dextran sodium sulfate (DSS)-induced colitis could differ between DSS preparations of the same molecular weight, and that this difference may be affected by the sulfur content. To test this, we used three DSS preparations of similar molecular weights but with different sulfur contents.Three DSS preparations with ...
Shigeki, Bamba +14 more
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Roquinimex inhibits dextran sodium sulfate-induced murine colitis
Inflammation Research, 2003Roquinimex is a modulator of the immune system and has been shown to attenuate induction of several inflammatory and autoimmune diseases. The objective of the present study was to determine the efficacy of roquinimex in a model of murine colitis.For this purpose, Balb/c mice were exposed to 5% dextran sodium sulfate (DSS) in the drinking water for five
Q, Liu +6 more
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Carcinogenicity of dextran sulfate sodium in relation to its molecular weight
Cancer Letters, 1983The carcinogenicity of dextran and 3 kinds of dextran sulfate sodium with different molecular weights and almost the same sulfur content were compared in ACI rats. Dextran sulfate sodium of molecular weight 54,000 showed a strong carcinogenic activity when it was given orally as 2.5% diet, whereas dextran sulfate sodium of molecular weight 520,000 and ...
I, Hirono +4 more
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