A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction. [PDF]
PLoS ONE, 2016 Chronic sleep restriction induces blood-brain barrier disruption and increases pro-inflammatory mediators in rodents. Those inflammatory mediators may modulate the blood-brain barrier and constitute a link between sleep loss and blood-brain barrier ...
Gabriela Hurtado-Alvarado +3 more
doaj +1 more source
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]
, 2019 Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin +10 more
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Improvement of a method for the characterization of ultrafiltration membranes by measurements of tracers retention [PDF]
, 2004 The aim of this study is to improve protocols for assessing accurate characteristic retention curve and cut-off of membranes, thus enabling the manufacture and performance of the membrane to be monitored. Different data treatments are considered in order
Aimar, Pierre +3 more
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Fluids and Barriers of the CNS, 2012 Background Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for intracerebral pharmacological therapy.
Barua Neil U +6 more
doaj +1 more source
Veins and Lymphatics, 2022 INTRODUCTION: The blood-brain barrier (BBB) is compromised in multiple central nervous system (CNS) disorders associated with neuroinflammation, including multiple sclerosis (MS).
Wenshen Wang +3 more
doaj +1 more source
A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]
, 2015 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T +4 more
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Dextranas em açúcares do estado de São Paulo Dextrans in lugars from São Paulo State
Química Nova, 2008 The characterization of dextran in sugars by size exclusion chromatography (SEC) has been carried out according to the number-average molecular weight (Mn), the weight-average molecular weight (Mw), the Z-average molecular weight (Mz), and the ...
Francisco Wendel Batista de Aquino +1 more
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Influence of ultrafiltration membrane characteristics on adsorptive fouling with dextrans [PDF]
, 2005 This paper presents a detailed investigation of fouling mechanisms for ultrafiltration membranes with polysaccharides obtained by studying membrane–solute (static adsorption) and membrane–solute–solute interactions (ultrafiltration (UF)).
Susanto, H., Ulbricht, M.
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Schistosoma mansoni cercariae experience influx of macromolecules during skin penetration [PDF]
, 2009 We have observed that when cercariae penetrate the skin of mice, there is influx into their tissues of Lucifer Yellow and certain labelled molecules of up to 20 kDa molecular weight.
Coelho, P.M.Z. +5 more
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Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro. [PDF]
PLoS ONE, 2015 Hypoglycemia impairs blood-brain barrier (BBB) endothelial function; a major hallmark in the pathogenesis of various CNS disorders. Previously, we have demonstrated that prolonged hypoglycemic exposure down-regulated BBB endothelial NF-E2 related factor ...
Ravi K Sajja +2 more
doaj +1 more source