Results 21 to 30 of about 29,023 (291)

Dextran-enhanced CEST MRI reveals the size effect of BBB dysfunction associated with neuroinflammation

Veins and Lymphatics, 2022
INTRODUCTION: The blood-brain barrier (BBB) is compromised in multiple central nervous system (CNS) disorders associated with neuroinflammation, including multiple sclerosis (MS).
Wenshen Wang, Jiadi Xu, Aline Thomas, Guanshu Liu   +3 more
doaj   +1 more source

A systematic approach to study the pH-dependent release, productivity and product specificity of dextransucrases

Microbial Cell Factories, 2019
Background Dextransucrases are extracellular enzymes, which catalyze the formation of α-1→6-linked glucose polymers from sucrose. These enzymes are exclusively expressed by lactic acid bacteria, which commonly acidify the extracellular environment due to
Jonas Schmid, Julia Bechtner, Rudi F. Vogel, Frank Jakob   +3 more
doaj   +1 more source

Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro. [PDF]

PLoS ONE, 2015
Hypoglycemia impairs blood-brain barrier (BBB) endothelial function; a major hallmark in the pathogenesis of various CNS disorders. Previously, we have demonstrated that prolonged hypoglycemic exposure down-regulated BBB endothelial NF-E2 related factor ...
Ravi K Sajja, Kayla N Green, Luca Cucullo   +2 more
doaj   +1 more source

Gold Nanoparticle-Mediated Photoporation Enables Delivery of Macromolecules over a Wide Range of Molecular Weights in Human CD4+ T Cells

Crystals, 2019
The modification of CD4+ T cells with exogenous nucleic acids or proteins is a critical step in several research and therapeutic applications, such as HIV studies and cancer immunotherapies.
Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan C. Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, Kevin Braeckmans   +10 more
doaj   +1 more source

Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity

Scientific Reports, 2023
Thermoresponsive polysaccharide-based materials with tunable transition temperatures regulating phase-separated microdomains offer substantial opportunities in tissue engineering and biomedical applications.
Saniya Yesmin Bubli, Matthew Smolag, Ellen Blackwell, Yung-Chun Lin, John G. Tsavalas, Linqing Li   +5 more
doaj   +1 more source

Evaluation of free radical‐induced structural changes and their effect on antioxidant and anti‐inflammatory activities of UV/H2O2‐degraded dextrans

eFood
Although ultraviolet (UV)/H2O2 treatment could effectively improve the bioactivities of polysaccharides, the relationship between free radical‐induced structural changes and the bioactivities of products remains unknown. Therefore, this work investigated
Biyang Zhu, Liuting Li, Kseniya Hileuskaya, Baojun Xu, Lijun You   +4 more
doaj   +1 more source

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

eLife, 2017
Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that ...
Alex J Smith, Xiaoming Yao, James A Dix, Byung-Ju Jin, Alan S Verkman   +4 more
doaj   +1 more source

Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. [PDF]

PLoS ONE, 2016
PURPOSE:Trabecular meshwork (TM) bypass surgeries attempt to enhance aqueous humor outflow (AHO) to lower intraocular pressure (IOP). While TM bypass results are promising, inconsistent success is seen.
Sindhu Saraswathy, James C H Tan, Fei Yu, Brian A Francis, David R Hinton, Robert N Weinreb, Alex S Huang   +6 more
doaj   +1 more source

Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions

Molecules, 2021
Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes.
Jeremy Gleaton, Ryan W. Curtis, Jean Chmielewski   +2 more
doaj   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source