Results 51 to 60 of about 38,208 (334)

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

Scientific Reports, 2020
Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine mucosal damage. While DXR does not induce gross loss of epithelium, others have shown elevated serum endotoxin after DXR administration.
Paul Cray, Breanna J. Sheahan, Jocsa E. Cortes, Christopher M. Dekaney   +3 more
doaj   +1 more source

Potential of novel dextran oligosaccharides as prebiotics for obesity management through in vitro experimentation [PDF]

, 2014
The energy-salvaging capacity of the gut microbiota from dietary ingredients has been proposed as a contributing factor for the development of obesity. This knowledge generated interest in the use of non-digestible dietary ingredients such as prebiotics ...
Deaville, Eddie R., Gibson, Glenn R., Kolida, Sofia, Rastall, Robert A., Sarbini, Shahrul Razid   +4 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Multifunctional Modification of Biologically Active Substances

Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 11. Estestvennye Nauki, 2014
The article studies the interracting of oxidized cyclic cyclodextrin dextrans (CD) with the protein - bacterial streptokinase. The oxidation was carried out with potassium periodate; free aldehyde groups were formed in CD molecule during this process ...
Moskvicheva Yana Borisovna, Petrovskiy Stanislav Viktorovich, Ginak Anatoliy Iosifovich   +2 more
doaj   +1 more source

Transdermal delivery of FITC-Dextrans with different molecular weights using radiofrequency microporation

Biomaterials Research, 2020
Background Transdermal delivery is of great importance for the effective delivery of bioactive or therapeutic agents into a body. The microporation device based on radiofrequency can be used to enhance delivery efficiency by removing the epidermis layer.
Guk Young Ahn, Hae-Seok Eo, Dongwon Kim, Sung-Wook Choi   +3 more
doaj   +1 more source

Characterizing anomalous diffusion in crowded polymer solutions and gels over five decades in time with variable-lengthscale fluorescence correlation spectroscopy [PDF]

, 2016
The diffusion of macromolecules in cells and in complex fluids is often found to deviate from simple Fickian diffusion. One explanation offered for this behavior is that molecular crowding renders diffusion anomalous, where the mean-squared displacement ...
Banks, Daniel S., Fradin, Cécile, Höfling, Felix, Peters, Robert D., Tressler, Charmaine   +4 more
core   +2 more sources

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Maleimidation of dextran and the application in designing a dextran–camptothecin conjugate

RSC Advances, 2018
In this study, we developed the maleimidiation of dextran and applied it in a camptothecin drug delivery system.
Qiwen Zhu, Bin Bao, Qiumeng Zhang, Jiahui Yu, Wei Lu   +4 more
openaire   +4 more sources

Dextrans in Aqueous Solution. Experimental Review on Intrinsic Viscosity Measurements and Temperature Effect [PDF]

, 2014
The study of biopolymers as dextran in aqueous solution, is effectively determined by intrinsic viscosity [η] measurements at different temperatures. Molecular weight (Mv) and hydrodynamic properties can be calculated from there.
Masuelli, Martin Alberto
core   +2 more sources

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source