Metabolites, 2022 The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-
Ajna Hamidovic +5 more
doaj +1 more source
THE PROTECTIVE EFFECT OF COQ10, DHEA AND THEIR COMBINATION IN REDUCED EMBRYOTOXICITY AND TERATOGENICITY FOR NORFLOXACIN IN PREGNANT FEMALE RATS [PDF]
Basrah Journal of Veterinary Research, 2018 This study was designed to evaluate the protective effect of CoQ10 and DHEA and their combination of norfloxacin induced embryotoxicity and teratogenicity in pregnant female rats and their fetuses. Twenty pregnant rats were divided equally into 5 groups,
doaj +1 more source
Association between prenatal androgens and cord blood androgens, a path analysis
Scientific Reports, 2023 To determine association paths between prenatal androgens and cord blood androgens. The concentrations of T, FT, DHT, DHEA and SHBG in prenatal venous blood and cord blood were measured in 342 pregnant women and their neonates.
Hui Xu +9 more
doaj +1 more source
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity [PDF]
Proceedings of the National Academy of Sciences, 1998 DHEA, together with DHEAS, is the most abundant steroid in the blood of young adult humans. Levels in humans decline with age and during certain types of illness or stress. We have found that DHEA(S) can prevent or reduce the neurotoxic actions in the hippocampus of the glutamate agonists N -methyl- d
V G, Kimonides +4 more
openaire +2 more sources
THE MECHANISMS OF SECONDARY OVARIAN FAILURE AT OPERATIONS ON THE PELVIC ORGANS (EXPERIMENTAL STUDY)
Акушерство, гинекология и репродукция, 2016 Objective - to establish a hysterectomy role in formation of secondary ovarian failure and to estimate possibility of application of DHEA. Materials and Methods. Sexually mature female rats outbred Wistar. Main group: 1a - hysterectomy + salpingectomy (n=
I. A. Petrov +6 more
doaj +1 more source
Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development
Developmental Cognitive Neuroscience, 2022 Dehydroepiandrosterone (DHEA) production is closely associated with the first pubertal hormonal event, adrenarche. Few studies have documented the relationships between DHEA and functional brain development, with even fewer examining the associations ...
Samantha H. Penhale +9 more
doaj +1 more source
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids [PDF]
Proceedings of the National Academy of Sciences, 1998 The observation was made that dehydroepiandrosterone (DHEA), as the unconjugated steroid, and its sulfate ester (DHEAS) are present in the brain of adult male rats (1). This finding was unforeseen because the rodent steroidogenic glands, including the adrenals, do not secrete significant amounts of DHEA (2).
E E, Baulieu, P, Robel
openaire +2 more sources
Journal of Ovarian Research, 2021 Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrinopathy that affects reproduction and metabolism. Mammalian target of rapamycin (mTOR) has been shown to participate in female reproduction under physiological and pathological ...
Zaixin Guo +3 more
doaj +1 more source
Analyzing Serum Level Changes in Dehydroepiandrosterone Sulfate, Dihydrotestosterone, Progesterone, and Prolactin after Radioactive Iodine Treatment for Papillary Thyroid Carcinoma [PDF]
Iranian Journal of Medical PhysicsIntroduction: Effective treatment of papillary thyroid carcinoma (PTC) is total thyroidectomy which is followed by radioactive iodine therapy (RIT) to ablate pathologic thyroid remnants and treat metastatic tumors.
Mehrosadat Alavi +2 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2021 Background Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes. This study aimed to investigate the in vitro and in vivo protective effects of DHEA against high glucose-induced oxidative stress in tenocytes and ...
Shintaro Mukohara +7 more
doaj +1 more source