Results 51 to 60 of about 16,325 (177)

Lower DHEA and DHEA-S response during acute psychosocial stress is related to higher perceived stress at work

European Journal of Psychotraumatology, 2012
Background : Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulfate (DHEA-S) increase during acute psychosocial stress is suggested to have a protective role against the negative consequences of cortisol.
Anna-Karin Lennartsson, Ingibjörg H. Jonsdottir   +1 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Dehydroepiandrosterone supplementation and the impact of follicular fluid metabolome and cytokinome profiles in poor ovarian responders

Journal of Ovarian Research, 2023
Background Poor ovarian responders (POR) are women undergoing in-vitro fertilization who respond poorly to ovarian stimulation, resulting in the retrieval of lower number of oocytes, and subsequently lower pregnancy rates.
Veronique Viardot-Foucault, Jieliang Zhou, Dexi Bi, Yoshihiko Takinami, Jerry. K. Y. Chan, Yie Hou Lee   +5 more
doaj   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Association of adrenal function and disease severity in community-acquired pneumonia.

PLoS ONE, 2014
IntroductionRapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to dehydroepiandrosterone (DHEA) ratio was put forward as a prognostic marker in sepsis.
Cornelia Mueller, Claudine A Blum, Michael Trummler, Daiana Stolz, Roland Bingisser, Christian Mueller, Michael Tamm, Beat Mueller, Philipp Schuetz, Mirjam Christ-Crain   +9 more
doaj   +1 more source

Chronic lithium treatment affects rat brain and serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) levels [PDF]

The International Journal of Neuropsychopharmacology, 2004
Lithium (Li) is an established effective treatment for bipolar disorder. However, the molecular mechanism of its action is still unknown. Dehydroepiandrosterone (DHEA) and its sulphate ester (DHEA-S) are adrenal hormones also synthesized de novo in the brain as neurosteroids. Recent studies have suggested that DHEA has mood-elevating properties and may
Rachel, Maayan, Galit, Shaltiel, Michael, Poyurovsky, Edward, Ramadan, Oren, Morad, Allon, Nechmad, Abraham, Weizman, Galila, Agam   +7 more
openaire   +2 more sources

A Single Centre Study to Describe the Changes in Serum Testosterone Concentration Following Application of Testosterone Gel in Post‐Menopausal Women With Hypoactive Sexual Desire Disorder (HSSD) Already Receiving This as Part of Usual Care in Conjunction With Oestrogen‐Containing Hormone Replacement Treatment (HRT)

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Hypoactive Sexual Desire Disorder (HSDD) is characterized by a long‐term decrease in sexual desire (low‐libido) causing personal distress. HSDD predominantly affects post‐menopausal women or following oophorectomy. Despite the clear indication that testosterone action could overcome the symptoms of HSDD by elevating testosterone ...
Adrian Heald, Yasitha Illangasekera, Hassan Rehman, Mark Livingston, Anne Keen, Rupinder Kochhar, Nicholas Panay, Joanna Borzomato, Mathilde Mordaunt, Peter Taylor, Geoff Hackett   +10 more
wiley   +1 more source

The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome

Taiwanese Journal of Obstetrics & Gynecology, 2018
Objective: Hyperandrogenism is the hallmark of polycystic ovary syndrome (PCOS). The use of dehydroepiandrosterone (DHEA)-treated rats is thought to be a suitable animal model to study PCOS.
Kok-Min Seow, Ching-Heng Ting, Seng-Wong Huang, Low-Tone Ho, Chi-Chang Juan   +4 more
doaj   +1 more source

The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, frequently accompanied by psychological comorbidities including depression. The aim of this narrative review is to summarise the latest research regarding potential contributors to and underpinning mechanisms of this relationship.
Asimina I. Karampela, Maralyn Druce
wiley   +1 more source

Serum dehydroepiandrosterone sulfate in assessing the integrity of the hypothalamic-pituitary-adrenal axis

Journal of Clinical & Translational Endocrinology, 2017
Objective: To evaluate the relationship between age- and gender-adjusted dehydroepiandrosterone sulfate (DHEA-S) levels and low-dose adrenocorticotropic hormone (ACTH) stimulation in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA ...
Suranut Charoensri, Laor Chailurkit, Dittapol Muntham, Pongamorn Bunnag   +3 more
doaj   +1 more source