Results 181 to 190 of about 10,008 (239)
DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence? [PDF]
Psychoneuroendocrinology, 2015 Background: Major depressive disorder (MDD) has been associated with low dehydroepiandrosterone-sulphate (DHEAS), - particularly relative to high cortisol - although conflicting findings exist.
Aart H Schene +2 more
exaly +3 more sources
CSF 5-HIAA, cortisol and DHEAS levels in suicide attempters
European Neuropsychopharmacology, 2013 The serotonin system and the hypothalamic-pituitary-adrenal (HPA) axis are involved in the biological vulnerability to suicidal behaviour. Altered levels of dehydroepiandrosterone (DHEA) and its sulphate ester DHEAS have been reported in neuropsychiatric
Jussi Jokinen +2 more
exaly +2 more sources
Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain [PDF]
FEBS Letters, 1998 Dehydroepiandrosterone sulfate (DHEAS) is the major circulating steroid in man. Pharmacologically, it exerts marked neuropsychiatric effects. Since no target receptor has been identified, we investigated whether the organic anion transporting polypeptide
Ulrich Beuers +2 more
exaly +2 more sources
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The Journal of Steroid Biochemistry and Molecular Biology, 2015
Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although observations in patients with inherited APA excess (e.g., patients with 21-hydroxylase ...
Mark O, Goodarzi +2 more
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Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although observations in patients with inherited APA excess (e.g., patients with 21-hydroxylase ...
Mark O, Goodarzi +2 more
openaire +2 more sources
The Journal of Clinical Pharmacology, 1999
Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to ...
P D, Kroboth +4 more
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Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA‐S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA‐S more than 50 years ago, there is still considerable controversy as to ...
P D, Kroboth +4 more
openaire +2 more sources
Selective Microbial Conversion of DHEA into 7α-OH-DHEA
20237α-Hydroxy dehydroepiandrosterone (7α-OH-prasterone, 7α-OH-DHEA) is a key steroid intermediate in the synthesis of valuable pharmaceuticals widely used in the treatment of autoimmune illness, rheumatoid arthritis, colitis, and other severe diseases. The steroid can be produced using a filamentous fungus, which is capable of regio- and stereospecific ...
Vyacheslav V, Kollerov +2 more
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Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer’s Disease
Current Alzheimer Research, 2020Background:Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer’s ...
Nedić Erjavec, Gordana +5 more
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Low Serum DHEAS Predicts Increased Fracture Risk in Older Men: The MrOS Sweden Study
Journal of Bone and Mineral Research, 2017 The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age.
Bjorn Rosengren +2 more
exaly +2 more sources
Biotransformation of DHEA into 7α,15α-diOH-DHEA
20173β,7α,15α-Trihydroxy-5-androsten-17-one (7α,15α-diOH-DHEA) is a key intermediate of the novel oral contraceptive "Yasmin" (widely used in birth control pills and postmenopausal hormone replacement therapy pills; the active ingredient is drospirenone).
Hui, Li, Jin, Sun, Zhenghong, Xu
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Lack of Hepatic Conversion of Dehydroepiandrosterone Sulfate (DHEAS) to DHEA
Endocrine Research, 2004DHEA and its sulfate ester DHEAS are the most abundant steroids in the human circulation. Only desulfated DHEA is biologically active and can be converted downstream toward sex steroids. The current concept is that DHEAS serves as the hydrophilic storage pool for DHEA regeneration and that DHEA and DHEAS are interconverted freely via hydroxysteroid ...
F, Hammer +6 more
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