Results 51 to 60 of about 237,902 (304)

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

The outcome of Gestational Diabetic pregnancies in the Maltese Islands [PDF]

, 2004
Gestational diabetes is generally associated with a higher morbidity and mortality for both the mother and child. Aims: The study aims to assess the outcome indicators of women suffering gestational diabetes and compare these to the remaining obstetric ...
Azzopardi, Joseph, Chircop, Marcelle, Ellul, Alan, Janulova, Lina, Savona-Ventura, Charles   +4 more
core  

Diagnosing gestational diabetes [PDF]

Diabetologia, 2011
The newly proposed criteria for diagnosing gestational diabetes will result in a gestational diabetes prevalence of 17.8%, doubling the numbers of pregnant women currently diagnosed. These new diagnostic criteria are based primarily on the levels of glucose associated with a 1.75-fold increased risk of giving birth to large-for-gestational age infants (
openaire   +2 more sources

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Genetic Abnormalities and Clinical Management of Fetal Genitourinary System Anomalies in Eastern China

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT To investigate the correlation between genetic abnormalities and fetal genitourinary (GU) anomalies in Eastern China and to provide assistance for the clinical management of fetuses with different types of GU anomalies. Five hundred forty‐five fetuses with GU anomalies were enrolled, undergoing karyotyping, copy number variation sequencing ...
Jie Liang, Jiebin Wu, Lin Zhang, Yunmeng Qi, Yi Wang, Xu Cao, Jingfang Zhai   +6 more
wiley   +1 more source

Birthweight and risk markers for type 2 diabetes and cardiovascular disease in childhood: the Child Heart and Health Study in England (CHASE). [PDF]

, 2015
AIMS/HYPOTHESIS: Lower birthweight (a marker of fetal undernutrition) is associated with higher risks of type 2 diabetes and cardiovascular disease (CVD) and could explain ethnic differences in these diseases. We examined associations between birthweight
A Bavdekar, A Lucas, Alicja R. Rudnicka, Angela S. Donin, AS Donin, AS Donin, B Park, BJ McNamara, C Li, C Thomas, Cathy M. McKay, CG Owen, Christopher G. Owen, Claire M. Nightingale, CM Law, CM Nightingale, CM Nightingale, CS Yajnik, DA Lawlor, Debbie A. Lawlor, Derek G. Cook, DJ Barker, DL Kuh, F Mzayek, GV Krishnaveni, I Shai, J West, JC Levy, Jennifer L. Bales, MC Franco, MR Skilton, Naveed Sattar, Office for National Statistics, P Fossati, Peter H. Whincup, PH Whincup, PH Whincup, PH Whincup, PH Whincup, PH Whincup, Phillip J. Steer, R Huxley, R Huxley, R Huxley, R Pfister, RS Bhopal, S Kodama, SH Wild, Sian L. Newton, SM Sayers, T Kaneshi, WB White, YK Tu   +52 more
core   +2 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway

Balkan Medical Journal, 2023
Background: T-cell death-associated gene 51 (TDAG51) belongs to the transcription factor family and is involved in the energy homeostasis of the liver through the regulation of lipogenesis.
Xiaozhi Wu, Biru Xiao
doaj   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

The Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson, Pierre Frémondière, Kaspar Staub, Philipp Mitteroecker, Barbara Fischer, Martin Haeusler, Nicole M. Webb   +6 more
wiley   +1 more source

Maternal and neonatal outcomes of gestational diabetes: A retrospective cohort study from Southern India

Journal of Family Medicine and Primary Care, 2015
Background: The prevalence of gestational diabetes is on the rise. Understanding the various outcomes of it is necessary to face this challenge. Objectives: To study the frequency of occurrence of various maternal and fetal outcomes among gestational ...
P R Sreelakshmi, Sanjeev Nair, Biju Soman, Rani Alex, K Vijayakumar, V Raman Kutty   +5 more
doaj   +1 more source