Results 61 to 70 of about 232,832 (287)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Gestational diabetes mellitus [PDF]

Journal of Clinical Investigation, 2005
Gestational diabetes mellitus (GDM) is defined as glucose intolerance of various degrees that is first detected during pregnancy. GDM is detected through the screening of pregnant women for clinical risk factors and, among at-risk women, testing for abnormal glucose tolerance that is usually, but not invariably, mild and asymptomatic.
Thomas A, Buchanan, Anny H, Xiang
openaire   +2 more sources

A Multicenter Collaborative Study on the Safety and Efficacy of Laparoscopic Appendectomy During Pregnancy

Annals of Gastroenterological Surgery, EarlyView.
Laparoscopic appendectomy (LA) during pregnancy was evaluated in a multicenter retrospective study in Japan. LA showed comparable maternal and fetal safety to open appendectomy (OA), supporting the feasibility and safety of LA in pregnant patients. ABSTRACT Aim Acute appendicitis in pregnant women requires accurate diagnosis and treatment because of ...
Katsuhiro Ogawa, Tomonori Akagi, Hidefumi Shiroshita, Hiroshi Yoshida, Masashi Miguchi, Ken Eto, Tetsuji Ohyama, Akiyoshi Kanazawa, Keiji Matsuda, Koya Hida, Seiichiro Yamamoto, Takeshi Naitoh, Masafumi Inomata, Japan Society of Laparoscopic Colorectal Surgery   +13 more
wiley   +1 more source

Mortality Patterns and Phenotypic Clusters in Trisomy 13: A Population‐Based Study From Japan

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Trisomy 13, the third most common autosomal trisomy after trisomy 21 and trisomy 18, is associated with a significantly high infant mortality rate. However, large‐scale studies examining causes of death in trisomy 13 remain scarce. Therefore, we aimed to better understand the mortality patterns.
Narumi Kato, Naho Morisaki, Akinori Moriichi   +2 more
wiley   +1 more source

Diabetes in Sub Saharan Africa 1999-2011: Epidemiology and Public Health Implications. A Systematic Review. [PDF]

, 2011
Diabetes prevalence is increasing globally, and Sub-Saharan Africa is no exception. With diverse health challenges, health authorities in Sub-Saharan Africa and international donors need robust data on the epidemiology and impact of diabetes in order to ...
Hall, Victoria, Henriksen, Ole, Lohse, Nicolai, Thomsen, Reimar W   +3 more
core   +2 more sources

Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status [PDF]

, 2020
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases). Amongst ART, in vitro fertilization (IVF) is the most popular.
Barber, Thomas M., Coussa, Ayla, Hassan, Hayder   +2 more
core   +1 more source

A Confirmatory Case of Severe Spondylocostal Dysostosis Caused by Biallelic Loss‐of‐Function of DMRT2

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Spondylocostal dysostosis (SCDO) is a rare genetic disorder characterized by abnormal development of the axial skeleton, resulting in malformations of the vertebrae and ribs that often impair lung development and lead to significant respiratory morbidity.
Jonathan Rips, Hagar Mor‐Shaked, Oded Shamriz, Raz Somech, Rawan Abu Omar, Smadar Eventov‐Friedman, Noa Ofek‐Shlomai, Dvorah Zaguer, Tamar Harel   +8 more
wiley   +1 more source

Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester [PDF]

, 2013
Context: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density ...
Brown, E.A., Caslake, M.J., Cooney, J., Freeman, D.J., Griffin, B.A., Meyer, B.J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Stewart, F.M.   +9 more
core   +2 more sources

The HRAS Variant c.175G>A (p.Ala59Thr) Causes a Predominantly Ectodermal Phenotype Lacking Classic Costello Syndrome Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is a rare dominant HRAS RASopathy characterized by curly hair, cardiac abnormalities, craniofacial anomalies, and developmental delay. HRAS codon 58, 59, and 60 variants are associated with milder phenotypes. We describe a three‐generation family with a previously unreported heterozygous HRAS variant c.175G>A (p.Ala59Thr)
Nikole Rautiainen, Eveliina Brandt, Kaisa Kettunen, Outi Elomaa, Sirpa Kivirikko, Leila Jeskanen, Katriina Lappalainen, Nelli Sjöblom, Juha Kere, Katariina Hannula‐Jouppi, Liisa Harjama   +10 more
wiley   +1 more source

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]

, 2019
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen, Gong, Lei, Li, Yong, Liu, Bailin, Xiao, Daliao, Zhang, Lubo, Zhang, Peng, Zhuang, Jian   +7 more
core