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Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury
Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo+10 more
wiley +1 more source
Obesity and diabetes in New Zealand [PDF]
Obesity is a risk factor for diabetes, cardiovascular disease, musculoskeletal disorders, and some cancers. Introduction It is estimated that 1.1 million adults are obese in New Zealand (that is, they have a BMI or Body Mass Index of 30 or more ...
Alexandra Marett
core
Å være ung og få diabetes [PDF]
Tema i denne oppgaven er unge i alderen 12-16 år og diabetes. I Norge er det i dag ca. 130 000 mennesker med diabetes. Av dem har om lag 25 000 diabetes mellitus type 1 (Kristensen, 1998). Diabetes type 1 er den vanligste hos barn, ungdom og unge voksne.
Gaugstad, Irene Gjøvåg
core
Conceptual study of malnutrition related diabetes mellitus [PDF]
The Diabetes mellitus (DM) is a metabolic disease characterized by absolute or relative insulin deficiency. Type 1 diabetes is commonly known as juvenile diabetes, because it typically strikes during childhood and sometimes adolescents, and young age ...
Dr. Borase Jayaprakash Balasaheb+1 more
core +3 more sources
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma+12 more
wiley +1 more source
Celebrating 100 Years of Insulin Use
The year 2022 marked the one-hundredth anniversary of the first application of insulin. November 14th, the birth date of one of its main discoverers, Frederick Banting, was designated as World Diabetes Day.
Zrinka Šakić+4 more
doaj
Polymorphic gene conferring susceptibility to insulin-dependent diabetes mellitus typed by ps-resolved FRET on nonamplified genomic DNA [PDF]
This work concerns the identification of the allelic sequences of the DQB1 gene of the human leukocyte antigen system conferring susceptibility to the development of insulin-dependent diabetes mellitus (IDDM) in DNA samples with no need of PCR amplification. Our method is based on the time-resolved analysis of a F\"orster energy-transfer mechanism that
arxiv
NPY Levels In Type 1 Diabetic Men of Different Duration. [PDF]
Background: The aim of the present study was to evaluate whether the different duration of type 1 diabetes mellitus influences basal NPY secretion. Design: The NPY concentrations were measured in sixty-eight men with insulin-dependent diabetes mellitus ...
Anna Araldi+10 more
core +1 more source
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma+13 more
wiley +1 more source