Results 201 to 210 of about 1,594,352 (310)
Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription Factor STAT4
Angewandte Chemie, EarlyView.The transcription factor STAT4 is a therapeutic target for autoimmune diseases. Here, para‐biaryl phosphates and phosphonates are presented as the first small‐molecule inhibitors of STAT4. The phosphonate Stafori‐1 selectively stabilizes STAT4 against thermal denaturation in cell lysates, and its cell‐permeable prodrug Pomstafori‐1 selectively inhibits
Nadiya Brovchenko +7 more
wiley +2 more sources
COMPARISON OF URINARY ALBUMIN EXCRETION RATE IN TYPE 1 AND TYPE 2 DIABETICS OF DISTRICT LAHORE
Gomal Journal of Medical Sciences, 2014 Background: The main cause of end-stage renal disease is diabetic nephropathy throughout the world. Renal disease in diabetics is characterized by increasing rates of urinary albumin excretion, starting from normoalbuminuria, which progresses to ...
Amir Rehman +3 more
doaj
Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis. [PDF]
PLoS One, 2021 Dirnena-Fusini I +4 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Using RNA‐seq and other bioinformatics analyses, three clusters of mitochondria related genes, including aldo‐keto reductase family 1 members B10 and B15 (AKR1B10, AKR1B15), alanyl‐tRNA synthetase 1 (AARS1), mitochondrial ribosomal protein S6 (MRPS6), mitochondrial calcium uniporter dominant negative subunit beta (MCUB) and dihydrolipoamide branched ...
Bin Wu +6 more
wiley +1 more source
Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model. [PDF]
Cornea, 2022 Amador-Muñoz DP +4 more
europepmc +1 more source
Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection
Animal Models and Experimental Medicine, EarlyView.This review explores the potential mechanisms, complications, risk factors, and future research directions related to osteoporosis secondary to SARS‐CoV‐2 infection. Key mechanisms include an imbalance between osteoclast and osteoblast activity driven by direct viral effects on bone, inflammation, hypoxia, dysregulation of noncoding RNAs, and metabolic
Jinlong Wang +5 more
wiley +1 more source
, 2017 Tittel: Diabetes type 1 Bakgrunn for val av tema: I 2000 var det ca. 130 000 personer i Norge med diabetes, av disse hadde ca. 20 000 diabetes type 1. I dag er det ca. 230 000 personer som har diabetes i Norge. Av disse ca. 28 000 type 1 diabetes.
openaire +1 more source
Animal Models and Experimental Medicine, EarlyView.Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat +6 more
wiley +1 more source
Predictors and morphological properties of culprit healed plaques in patients with angina pectoris
Clinical Cardiology, Volume 45, Issue 12, Page 1199-1210, December 2022., 2022 Abstract Background Plaque healing may serve a vital function in the natural progression of atherosclerotic disease. This study sought to investigate predictors and morphological characteristics of healed plaque (HP) among angina pectoris (AP) patients.
Hongying Yao +5 more
wiley +1 more source