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Research progress on ferroptosis in diabetic kidney disease
Frontiers in Endocrinology, 2022 Ferroptosis is a newly discovered form of cell death that differs from other forms of regulated cell death at morphological, biochemical, and genetic levels, and is characterized by iron-dependent accumulation of lipid peroxides.
You Wu, Yan Chen
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Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Nature Communications, 2019 Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate
Koichi Kikuchi +55 more
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Renal biopsy in diabetic patients: Histopathological and clinical correlations [PDF]
Revista Portuguesa de Nefrologia e Hipertensão, 2021 Introduction: Diabetes is the leading cause of chronic kidney disease and end-stage kidney disease worldwide. A kidney biopsy in a diabetic patient must be considered when non-diabetic renal disease is suspected, such as in the presence of a rapid ...
Joana Paixão +10 more
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Research progress of single nucleotide polymorphisms and immune cells in diabetic kidney disease [PDF]
Jichu yixue yu linchuang, 2022 Diabetic kidney disease has obvious family aggregation and ethnic differences, some single nucleotide polymorphisms (SNPs) related to the susceptibility of diabetic kidney disease have been identified, especially engulfment and cell motility 1 (ELMO1 ...
GUO Meng-ran, MIN Hang, YE Yue, XU Xiao-shuang, ZHEN Dong-hu
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Metabolic phenotypes and risk of end-stage kidney disease in patients with type 2 diabetes
Frontiers in Endocrinology, 2023 BackgroundObesity often initiates or coexists with metabolic abnormalities. This study aimed to investigate the pathological characteristics and the independent or mutual relations of obesity and metabolic abnormalities with end-stage kidney disease ...
Lijun Zhao +12 more
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Molecular pathways that drive diabetic kidney disease
Journal of Clinical Investigation, 2023 Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases. DKD usually develops in a genetically susceptible individual as a result of
Samer Mohandes +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Purpose: This study aimed to investigate the effects of intravitreal (IVT) VEGFi on long-term renal outcomes in patients with biopsy-proven diabetic kidney disease (DKD).Patients and methods: Patients prescribed IVT VEGFi (VEGFi group) were enrolled from
Xiang Xiao +19 more
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Exploring molecular targets in diabetic kidney disease [PDF]
Kidney Research and Clinical Practice, 2022 Diabetic kidney disease is the leading cause of end-stage kidney disease, and it remains a major challenge. Many factors, such as glomerular hyperfiltration, oxidative stress, inflammation, hypoxia, and epigenetics, are associated with the progression of
Sayako Maruno +2 more
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Frontiers in Endocrinology, 2022 AimsAbnormalities of glucolipid metabolism are critical mechanisms involved in the progression of diabetic kidney disease (DKD). Bile acids have an essential role in regulating glucolipid metabolism.
Xiang Xiao +18 more
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Frontiers in Endocrinology, 2022 Objective Diabetic kidney disease (DKD) is the most common chronic kidney disease (CKD) and has the highest prevalence of end-stage kidney disease (ESKD) globally, owing mostly to the rise in Type 2 diabetes mellitus (T2DM) correlated with obesity ...
Wencong Guo +7 more
semanticscholar +1 more source