Use of Anti-Diabetic Agents in Non-Diabetic Kidney Disease: From Bench to Bedside
Life, 2021 New drugs were recently developed to treat hyperglycemia in patients with type 2 diabetes mellitus (T2D). However, metformin remains the first-line anti-diabetic agent because of its cost-effectiveness.
Sungjin Chung, Gheun-Ho Kim
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Hyperglycemia and Hyperlipidemia Act Synergistically to Induce Renal Disease in LDL Receptor-Deficient BALB Mice [PDF]
, 2004 Diabetic nephropathy is the leading cause of end-stage renal disease in Western countries, but only a portion of diabetic patients develop diabetic nephropathy.
Segerer, Stephan +7 more
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Research progress on ferroptosis in diabetic kidney disease
Frontiers in Endocrinology, 2022 Ferroptosis is a newly discovered form of cell death that differs from other forms of regulated cell death at morphological, biochemical, and genetic levels, and is characterized by iron-dependent accumulation of lipid peroxides.
You Wu, Yan Chen
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TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]
, 2010 Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
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Cells, 2021 Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes mellitus. Several factors are involved in its pathophysiology.
Claudio D. Gonzalez +4 more
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Kidney disease management in UK primary care: guidelines, incentives and Information Technology [PDF]
, 2007 The last few years have seen new developments to understand and tackle the significant public health issue posed by chronic kidney disease (CKD). Established renal disease currently consumes 2% of the UK National Health Service budget and predictions are
O'Donoghue, Donal J. +7 more
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Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans [PDF]
, 2008 Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
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Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria
Frontiers in Medicine, 2021 The prevalence of diabetes reaches epidemic proportions. Diabetes is the leading cause of end-stage kidney disease (ESKD) since 30–40% of diabetic patients develop diabetic nephropathy.
Rajkishor Nishad +6 more
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Diabetic kidney disease: the kidney disease relevant to individuals with diabetes
Clinical and Experimental NephrologyAbstractIn individuals with diabetes, chronic kidney disease (CKD) is a major comorbidity. However, it appears that there is worldwide confusion regarding which term should be used to describe CKD complicated with diabetes: diabetic nephropathy, diabetic kidney disease (DKD), CKD with diabetes, diabetes and CKD, etc.
Keizo Kanasaki +2 more
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Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease
Frontiers in Endocrinology, 2018 Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the
Lauren Winter +11 more
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